The Alzheimer's disease (AD) therapeutic research is yielding a large number of potent
molecules. The nanoparticle-based therapeutics against the protein aggregation in AD is …

Abstract Alzheimer's disease (AD), one of the major tauopathies, is multifactorial with a
massive demand for disease-modifying treatments rather than symptom management. An …

Background Alzheimer's disease is associated with the accumulation of intracellular Tau
tangles within neurons and extracellular amyloid-β plaques in the brain parenchyma, which …

Tau aggregation and accumulation is a key event in the pathogenesis of Alzheimer's
disease. Inhibition of Tau aggregation is therefore a potential therapeutic strategy to …

The neuronal cytoskeleton plays a crucial role in maintaining cell integrity and functioning of
neurons. Cytoskeleton deformities have been reported to be associated with …

Alzheimer's disease is characterized by important patho-proteins, which being composed of
Amyloid-β plaques and intracellular neurofibrillary tangles of Tau. Intrinsically disordered …

Microglia, the resident immune cells, were found to be activated to inflammatory phenotype
in Alzheimer's disease (AD). The extracellular burden of amyloid-β plaques and Tau seed …

Tau is an axonal protein known to form abnormal aggregates and is the biomarker of
Alzheimer's disease. Metal-based therapeutics for inhibition of Tau aggregation is limited …

Tau is the major neuronal protein involved in the stabilization of microtubule assembly. In
Alzheimer's disease, Tau self-assembles to form intracellular protein aggregates which are …

The RNA degradosome is a multi-enzyme assembly that plays a central role in the RNA
metabolism of Escherichia coli and numerous other bacterial species including pathogens …