[HTML][HTML] Silica nanoparticles: A review of their safety and current strategies to overcome biological barriers

TI Janjua, Y Cao, F Kleitz, M Linden, C Yu… - Advanced Drug Delivery …, 2023 - Elsevier
Silica nanoparticles (SNP) have gained tremendous attention in the recent decades. They
have been used in many different biomedical fields including diagnosis, biosensing and …

Current advance of nanotechnology in diagnosis and treatment for malignant tumors

B Wang, S Hu, Y Teng, J Chen, H Wang, Y Xu… - … and Targeted Therapy, 2024 - nature.com
Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …

Intracavity generation of glioma stem cell–specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy

C Chen, W **g, Y Chen, G Wang, M Abdalla… - Science translational …, 2022 - science.org
Glioblastoma multiforme (GBM) remains incurable despite aggressive implementation of
multimodal treatments after surgical debulking. Almost all patients with GBM relapse within a …

Immunotherapy: a promising approach for glioma treatment

F Yasinjan, Y **ng, H Geng, R Guo, L Yang… - Frontiers in …, 2023 - frontiersin.org
Gliomas are the most prevalent primary malignant brain tumors worldwide, with
glioblastoma (GBM) being the most common and aggressive type. Despite two decades of …

Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives

H Lin, C Liu, A Hu, D Zhang, H Yang, Y Mao - Journal of hematology & …, 2024 - Springer
Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …

Engineered extracellular vesicle-delivered CRISPR/Cas9 for radiotherapy sensitization of glioblastoma

X Liu, Z Cao, W Wang, C Zou, Y Wang, L Pan, B Jia… - ACS …, 2023 - ACS Publications
Radiotherapy is a mainstay of glioblastoma (GBM) treatment; however, the development of
therapeutic resistance has hampered the efficacy of radiotherapy, suggesting that additional …

Tumor-derived exosomes deliver the tumor suppressor miR-3591-3p to induce M2 macrophage polarization and promote glioma progression

M Li, H Xu, Y Qi, Z Pan, B Li, Z Gao, R Zhao, H Xue… - Oncogene, 2022 - nature.com
Exosomes can selectively secrete harmful metabolic substances from cells to maintain
cellular homeostasis, and complex crosstalk occurs between exosomes and tumor …

[HTML][HTML] Advances in diagnostic tools and therapeutic approaches for gliomas: a comprehensive review

G Thenuwara, J Curtin, F Tian - Sensors, 2023 - mdpi.com
Gliomas, a prevalent category of primary malignant brain tumors, pose formidable clinical
challenges due to their invasive nature and limited treatment options. The current …

Receptor ligand-free mesoporous silica nanoparticles: a streamlined strategy for targeted drug delivery across the blood–brain barrier

ZA Chen, CH Wu, SH Wu, CY Huang, CY Mou… - ACS …, 2024 - ACS Publications
Mesoporous silica nanoparticles (MSNs) represent a promising avenue for targeted brain
tumor therapy. However, the blood–brain barrier (BBB) often presents a formidable obstacle …

Immunotherapy in glioblastoma treatment: Current state and future prospects

SLR Pinheiro, FFB Lemos, HS Marques… - World Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Glioblastoma remains as the most common and aggressive malignant brain tumor, standing
with a poor prognosis and treatment prospective. Despite the aggressive standard care …