The GATA family of transcription factors is of crucial importance during embryonic
development, playing complex and widespread roles in cell fate decisions and tissue …

The hypothalamus‐pituitary‐thyroid (HPT) axis determines the set point of thyroid hormone
(TH) production. Hypothalamic thyrotropin‐releasing hormone (TRH) stimulates the …

The anterior pituitary gland plays a central role in regulating various physiological
processes, including body growth, reproduction, metabolism and stress response. Here, we …

Gene regulatory networks are the most complex, extensive control systems found in nature.
The interaction between biology and evolution has been the subject of great interest in …

Using molecular, cellular, and genetic approaches, recent studies examining the role of the
bone morphogenetic protein (BMP) family of growth factors in the reproductive system have …

Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …

The initial source of IL-4-inducing Th2 development and the mechanism of stable Th2
commitment remain obscure. We found the reduced level of IL-4 production in Stat6 …

Abstract Pitx1 (refs,,) and Pitx2 (refs,) are highly homologous, bicoid-related transcription
factors. Pitx2 was initially identified as the gene responsible for the human Rieger syndrome …

The pituitary gland has provided unique insight into molecular mechanisms and regulatory
factors controling both differentiation and gene transcription. We identified Tpit, a novel T …

The recognition of polarized T cell subsets defined by cytokine production was followed by a
search to define the factors controlling this phenomenon. Suitable in vitro systems allowed …