Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Cyclic peptides are fascinating molecules abundantly found in nature and exploited as
molecular format for drug development as well as other applications, ranging from research …

Rapid‐acting, convenient, and broadly applicable medical materials are in high demand for
the treatment of extensive and intricate tissue injuries in extremely medical scarcity …

Rational design of next-generation therapeutics can be facilitated by high-resolution
structures of drug targets bound to small-molecule inhibitors. However, application of …

Highlights•AlphaFold models have rigid protein structures.•Advanced deep algorithms fed
relevant data can accurately predict structures.•Algorithmic advances can harness …

Integrins link the extracellular environment to the actin cytoskeleton in cell migration and
adhesiveness. Rapid coordination between events outside and inside the cell is essential …

Integrins are main cell adhesion receptors serving as linker attaching cells to extracellular
matrix (ECM) and bidirectional hubs transmitting biochemical and mechanical signals …

Integrins are heterodimeric glycoproteins crucial to the physiology and pathology of many
biological functions. As adhesion molecules, they mediate immune cell trafficking, migration …

Abstract The RGD (Arg-Gly-Asp)-binding integrins αvβ6 and αvβ8 are clinically validated
cancer and fibrosis targets of considerable therapeutic importance. Compounds that can …

Venous thrombosis (VT) is a common vascular disease associated with reduced survival
and a high recurrence rate. VT is initiated by the accumulation of platelets and neutrophils at …