The attachment of cells to the extracellular matrix (ECM) is the hallmark of structure–function
stability and well-being. ECM detachment in localized tumors precedes abnormal …

Heat shock proteins (HSP) are expressed at high levels in cancer and form a fostering
environment that is essential for tumor development. Here, we review the recent data in this …

Epithelial cells require attachment to the extracellular matrix (ECM) for survival. However,
during tumour progression and metastasis, cancerous epithelial cells must adapt to and …

The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …

Breast cancer exhibits the highest global incidence among all tumor types. Regardless of
the type of breast cancer, metastasis is a crucial cause of poor prognosis. Anoikis, a form of …

Balancing cell death and survival is essential for normal development and homeostasis and
for preventing diseases, especially cancer. Conventional cell death pathways include …

Hypoxic tumors are associated with poor clinical outcome for multiple types of human
cancer. This may be due, in part, to hypoxic cancer cells being resistant to anticancer …

Glioma is the most common malignant intracranial tumor and exhibits diffuse metastasis and
a high recurrence rate. The invasive property of glioma results from cell detachment. Anoikis …

There is increasing interest in therapeutically exploiting metabolic differences between
normal and cancer cells. We show that kinase inhibitors (KIs) and biguanides synergistically …

Cancer complexity constantly challenges the way that clinicians manage breast cancer
therapy. Tumor heterogeneity and intratumoral stroma characteristics allow cells with …