Acute actions and novel targets of matrix metalloproteinases in the heart and vasculature
Matrix metalloproteinases (MMPs) have been shown to play significant roles in a number of
physiological as well as pathological processes. Best known to proteolyse components of …
physiological as well as pathological processes. Best known to proteolyse components of …
Calpains as potential anti-cancer targets
L Leloup, A Wells - Expert opinion on therapeutic targets, 2011 - Taylor & Francis
Introduction: The intracellular signaling cysteine proteases, calpains (specifically the
ubiquitous calpains 1 and 2), are involved in numerous physiological and pathological …
ubiquitous calpains 1 and 2), are involved in numerous physiological and pathological …
[HTML][HTML] Recent progress in vascular aging: mechanisms and its role in age-related diseases
As with many age-related diseases including vascular dysfunction, age is considered an
independent and crucial risk factor. Complicated alterations of structure and function in the …
independent and crucial risk factor. Complicated alterations of structure and function in the …
Cathepsin and calpain inhibitor E64d attenuates matrix metalloproteinase-9 activity after focal cerebral ischemia in rats
Background and Purpose—Matrix metalloproteinases (MMPs) and cysteine proteases
(calpain and cathepsin B) play an important role in cell death and are upregulated after focal …
(calpain and cathepsin B) play an important role in cell death and are upregulated after focal …
Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells
L Jiang, M Wang, J Zhang, RE Monticone… - PloS one, 2008 - journals.plos.org
Background Angiotensin II (Ang II) signaling, including matrix metalloproteinase type II
(MMP2) activation, has been linked to an age-associated increase in migration capacity of …
(MMP2) activation, has been linked to an age-associated increase in migration capacity of …
Involvement of CD147 in overexpression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1
J Zhou, P Zhu, JL Jiang, Q Zhang, ZB Wu, XY Yao… - BMC cell biology, 2005 - Springer
Background During infection and inflammation, circulating blood monocytes migrate from
the intravascular compartments to the extravascular compartments, where they mature into …
the intravascular compartments to the extravascular compartments, where they mature into …
Homocysteine-mediated activation and mitochondrial translocation of calpain regulates MMP-9 in MVEC
Hyperhomocysteinemia (HHcy) is associated with atherosclerosis, stroke, and dementia.
Hcy causes extracellular matrix remodeling by the activation of matrix metalloproteinase-9 …
Hcy causes extracellular matrix remodeling by the activation of matrix metalloproteinase-9 …
Oxidative phosphorylation dysfunction modulates expression of extracellular matrix—remodeling genes and invasion
C van Waveren, Y Sun, HS Cheung… - …, 2006 - academic.oup.com
A number of recent studies suggest that mitochondrial function is a player in tumor
development and progression. In this study, we have used gene expression arrays to …
development and progression. In this study, we have used gene expression arrays to …
Calpain in breast cancer: role in disease progression and treatment response
The calpains are a family of intracellular cysteine proteases that function in a wide array of
cellular activities, including cytoskeletal remodelling, survival and apoptosis. The …
cellular activities, including cytoskeletal remodelling, survival and apoptosis. The …
Modulators of calpain activity: inhibitors and activators as potential drugs
ABSTRACT Introduction: Calpains are intracellular Ca2+-dependent cysteine proteases with
15 known members in the enzyme family. They act as regulatory enzymes, their cleavage …
15 known members in the enzyme family. They act as regulatory enzymes, their cleavage …