Nuclear receptors as therapeutic targets for neurodegenerative diseases: lost in translation
Neurodegenerative diseases are characterized by a progressive loss of neurons that leads
to a broad range of disabilities, including severe cognitive decline and motor impairment, for …
to a broad range of disabilities, including severe cognitive decline and motor impairment, for …
Human iPSC-derived endothelial cells and microengineered organ-chip enhance neuronal development
Human stem cell-derived models of development and neurodegenerative diseases are
challenged by cellular immaturity in vitro. Microengineered organ-on-chip (or Organ-Chip) …
challenged by cellular immaturity in vitro. Microengineered organ-on-chip (or Organ-Chip) …
A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a devastating progressive motor neuron disease that
affects people of all ethnicities. Approximately 90% of ALS cases are sporadic and thought …
affects people of all ethnicities. Approximately 90% of ALS cases are sporadic and thought …
FUS mutant human motoneurons display altered transcriptome and microRNA pathways with implications for ALS pathogenesis
The FUS gene has been linked to amyotrophic lateral sclerosis (ALS). FUS is a ubiquitous
RNA-binding protein, and the mechanisms leading to selective motoneuron loss …
RNA-binding protein, and the mechanisms leading to selective motoneuron loss …
Neurodegenerative diseases have genetic hallmarks of autoinflammatory disease
RI Richards, SA Robertson… - Human molecular …, 2018 - academic.oup.com
The notion that one common pathogenic pathway could account for the various clinically
distinguishable, typically late-onset neurodegenerative diseases might appear unlikely …
distinguishable, typically late-onset neurodegenerative diseases might appear unlikely …
Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis
Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease
involving loss of motor neurons and having no known cure and uncertain etiology. Several …
involving loss of motor neurons and having no known cure and uncertain etiology. Several …
[HTML][HTML] ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons
S Harjuhaahto, TS Rasila, SM Molchanova… - Neurobiology of …, 2020 - Elsevier
Mitochondrial intermembrane space proteins CHCHD2 and CHCHD10 have roles in motor
neuron diseases such as amyotrophic lateral sclerosis, spinal muscular atrophy and axonal …
neuron diseases such as amyotrophic lateral sclerosis, spinal muscular atrophy and axonal …
Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson's, Alzheimer's and ALS …
R Patel, C Brophy, M Hickling, J Neve, A Furger - BMC Medical Genomics, 2019 - Springer
Background Transcriptome wide changes have been assessed extensively during the
progression of neurodegenerative diseases. Alternative polyadenylation (APA) occurs in …
progression of neurodegenerative diseases. Alternative polyadenylation (APA) occurs in …
Gene targeting in amyotrophic lateral sclerosis using causality-based feature selection and machine learning
Background Amyotrophic lateral sclerosis (ALS) is a rare progressive neurodegenerative
disease that affects upper and lower motor neurons. As the molecular basis of the disease is …
disease that affects upper and lower motor neurons. As the molecular basis of the disease is …
C9orf72-associated SMCR8 protein binds in the ubiquitin pathway and with proteins linked with neurological disease
JL Goodier, AO Soares, GC Pereira, LR DeVine… - Acta Neuropathologica …, 2020 - Springer
A pathogenic GGGCCC hexanucleotide expansion in the first intron/promoter region of the
C9orf72 gene is the most common mutation associated with amyotrophic lateral sclerosis …
C9orf72 gene is the most common mutation associated with amyotrophic lateral sclerosis …