Nuclear receptors as therapeutic targets for neurodegenerative diseases: lost in translation
Neurodegenerative diseases are characterized by a progressive loss of neurons that leads
to a broad range of disabilities, including severe cognitive decline and motor impairment, for …
to a broad range of disabilities, including severe cognitive decline and motor impairment, for …
Human iPSC-derived endothelial cells and microengineered organ-chip enhance neuronal development
Human stem cell-derived models of development and neurodegenerative diseases are
challenged by cellular immaturity in vitro. Microengineered organ-on-chip (or Organ-Chip) …
challenged by cellular immaturity in vitro. Microengineered organ-on-chip (or Organ-Chip) …
A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a devastating progressive motor neuron disease that
affects people of all ethnicities. Approximately 90% of ALS cases are sporadic and thought …
affects people of all ethnicities. Approximately 90% of ALS cases are sporadic and thought …
FUS mutant human motoneurons display altered transcriptome and microRNA pathways with implications for ALS pathogenesis
The FUS gene has been linked to amyotrophic lateral sclerosis (ALS). FUS is a ubiquitous
RNA-binding protein, and the mechanisms leading to selective motoneuron loss …
RNA-binding protein, and the mechanisms leading to selective motoneuron loss …
Neurodegenerative diseases have genetic hallmarks of autoinflammatory disease
RI Richards, SA Robertson… - Human molecular …, 2018 - academic.oup.com
The notion that one common pathogenic pathway could account for the various clinically
distinguishable, typically late-onset neurodegenerative diseases might appear unlikely …
distinguishable, typically late-onset neurodegenerative diseases might appear unlikely …
Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis
Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease
involving loss of motor neurons and having no known cure and uncertain etiology. Several …
involving loss of motor neurons and having no known cure and uncertain etiology. Several …
[HTML][HTML] ALS and Parkinson's disease genes CHCHD10 and CHCHD2 modify synaptic transcriptomes in human iPSC-derived motor neurons
S Harjuhaahto, TS Rasila, SM Molchanova… - Neurobiology of …, 2020 - Elsevier
Mitochondrial intermembrane space proteins CHCHD2 and CHCHD10 have roles in motor
neuron diseases such as amyotrophic lateral sclerosis, spinal muscular atrophy and axonal …
neuron diseases such as amyotrophic lateral sclerosis, spinal muscular atrophy and axonal …
Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson's, Alzheimer's and ALS …
R Patel, C Brophy, M Hickling, J Neve, A Furger - BMC Medical Genomics, 2019 - Springer
Background Transcriptome wide changes have been assessed extensively during the
progression of neurodegenerative diseases. Alternative polyadenylation (APA) occurs in …
progression of neurodegenerative diseases. Alternative polyadenylation (APA) occurs in …
Gene targeting in amyotrophic lateral sclerosis using causality-based feature selection and machine learning
Background Amyotrophic lateral sclerosis (ALS) is a rare progressive neurodegenerative
disease that affects upper and lower motor neurons. As the molecular basis of the disease is …
disease that affects upper and lower motor neurons. As the molecular basis of the disease is …
The enemy within: innate surveillance-mediated cell death, the common mechanism of neurodegenerative disease
Neurodegenerative diseases comprise an array of progressive neurological disorders all
characterized by the selective death of neurons in the central nervous system. Although, rare …
characterized by the selective death of neurons in the central nervous system. Although, rare …