Worldwide, stroke is a leading cause of death and disability. Recombinant tissue
plasminogen activator (rtPA) was approved a decade ago for the treatment of acute ischemic …

Background—Neuroprotective drugs for acute stroke have appeared to work in animals,
only to fail when tested in humans. With the failure of so many clinical trials, the future of …

Perfusion computed tomography (CT) is a relatively new technique that allows rapid
qualitative and quantitative evaluation of cerebral perfusion by generating maps of cerebral …

CT perfusion (CTP) is a functional imaging technique that provides important information
about capillary-level hemodynamics of the brain parenchyma and is a natural complement …

Anumber of techniques have been developed during the past four decades to evaluate
cerebral perfusion. The oldest used 133Xe, a lipophilic radioactive tracer that easily diffuses …

PURPOSE: To measure mean cerebral blood flow (CBF) in ischemic and nonischemic
territories and in low-attenuation regions in patients with acute stroke by using …

BACKGROUND AND PURPOSE: Blood vessels are usually conspicuous on dynamic CT
perfusion images. The presence of large vessels may lead to overestimation of the …

The number of potential patients who are actually treated for acute ischemic stroke is
disappointingly low, and effective treatments are making a minor impact on this major public …

Since its introduction three decades ago, computed tomography (CT) has been regarded as
an imaging technique that is good at providing structural information but poor at providing …

Background and Purpose—Diffusion-weighted imaging (DWI) can reliably identify critically
ischemic tissue shortly after stroke onset. We tested whether thresholded computed …