Cohesin mediates chromatin loop formation across the genome by extruding chromatin
between convergently oriented CTCF-binding elements. Recent studies indicate that …

IgE not only provides protective immunity against helminth parasites but can also mediate
the type I hypersensitivity reactions that contribute to the pathogenesis of allergic diseases …

Antibody class switch recombination (CSR) in B lymphocytes replaces immunoglobulin
heavy chain locus (Igh) Cμ constant region exons (CHs) with one of six CHs lying 100–200 …

IgE antibodies with high affinity for their antigens can be stably cross-linked at low
concentrations by trace amounts of antigen, whereas IgE antibodies with low affinity bind …

Upon encountering antigens, mature IgM-positive B lymphocytes undergo class-switch
recombination (CSR) wherein exons encoding the default Cμ constant coding gene …

The B cell receptor (BCR) is expressed on the B lymphocyte cell surface where it serves as a
receptor for foreign antigens (1). The BCR is comprised of two immunoglobulin (Ig) heavy …

Epithelial cells respond to physicochemical damage with up-regulation of major
histocompatibility complex–like ligands that can activate the cytolytic potential of …

During B-cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH)
V, D, and J gene segments and orchestrates their fusion as deletional events that assemble …

Immunoglobulin E (IgE) plays an important role in allergic diseases. Nevertheless, the
source of IgE serological memory remains controversial. We reexamined the mechanism of …

Gene expression profiling has identified two major molecular subtypes of diffuse large B-cell
lymphoma (DLBCL) that are histologically indistinguishable but differ in cure rates. Here, we …