Tissue-resident-memory T cells (TRM) populate the body's barrier surfaces, functioning as
frontline responders against reencountered pathogens. Understanding of the mechanisms …

The Alphaherpesvirinae subfamily includes HSV types 1 and 2 and the sequence-divergent
pathogen varicella zoster virus (VZV). T cells, controlled by TCR and HLA molecules that …

Merkel cell carcinoma (MCC) is often caused by persistent expression of Merkel cell
polyomavirus (MCPyV) T-antigen (T-Ag). These non-self proteins comprise about 400 amino …

SARS-CoV-2 provokes a robust T cell response. Peptide-based studies exclude antigen
processing and presentation biology, which may influence T cell detection studies. To focus …

Herpes zoster is a localized skin infection caused by reactivation of latent varicella-zoster
virus. Tissue-resident T cells likely control skin infections. Zoster provides a unique …

Antigen-specific TRM persist and protect against skin or female reproductive tract (FRT) HSV
infection. As the pathogenesis of HSV differs between humans and model organisms, we …

Herpes simplex virus (HSV) infection is restricted to epithelial cells and neurons and is
controlled by CD8 T cells. These cells both traffic to epithelial sites of recurrent lytic infection …

Little is known concerning immunodominance within the CD4 T-cell response to viral
infections and its persistence into long-term memory. We tested CD4 T-cell reactivity against …

Elicitation of CD4 IFN-gamma T cell responses to Mycobacterium tuberculosis (MTB) is a
rational vaccine strategy to prevent clinical tuberculosis. Diagnosis of MTB infection is based …

Background Orolabial herpes simplex virus type 1 (HSV-1) infection has a wide spectrum of
severity in immunocompetent persons. To study the role of viral genotype and host immunity …