Tissue and organ development during embryogenesis relies on the collective and
coordinated action of many cells. Recent studies have revealed that tissue material …

Collective cell migration is a key driver of embryonic development, wound healing, and
some types of cancer invasion. Here, we provide a physical perspective of the mechanisms …

The physical state of embryonic tissues emerges from non-equilibrium, collective
interactions among constituent cells. Cellular jamming, rigidity transitions and characteristics …

Collective cell motility is crucial to many biological processes including morphogenesis,
wound healing, and cancer invasion. Recently, the biology and biophysics communities …

We present an approach to understand geometric-incompatibility–induced rigidity in
underconstrained materials, including subisostatic 2D spring networks and 2D and 3D …

Experiments and theory have shown that cell monolayers and epithelial tissues exhibit solid-
liquid and glass-liquid transitions. These transitions are biologically relevant to our …

Models for confluent biological tissues often describe the network formed by cells as a triple-
junction network, similar to foams. However, higher-order vertices or multicellular rosettes …

We study the influence of cell-level mechanical heterogeneity in epithelial tissues using a
vertex-based model. Heterogeneity is introduced into the cell shape index (p 0) that tunes …

Jamming of cell collectives and associated rigidity transitions have been shown to play a key
role in tissue dynamics, structure and morphogenesis. Cellular jamming is controlled by …

Dorsal closure is a process that occurs during embryogenesis of Drosophila melanogaster.
During dorsal closure, the amnioserosa (AS), a one-cell thick epithelial tissue that fills the …