Reduction of substrates by nitrogenases

LC Seefeldt, ZY Yang, DA Lukoyanov, DF Harris… - Chemical …, 2020 - ACS Publications
Nitrogenase is the enzyme that catalyzes biological N2 reduction to NH3. This enzyme
achieves an impressive rate enhancement over the uncatalyzed reaction. Given the high …

Structural enzymology of nitrogenase enzymes

O Einsle, DC Rees - Chemical reviews, 2020 - ACS Publications
The reduction of dinitrogen to ammonia by nitrogenase reflects a complex choreography
involving two component proteins, MgATP and reductant. At center stage of this process …

Quantum chemical studies of mechanisms for metalloenzymes

MRA Blomberg, T Borowski, F Himo, RZ Liao… - Chemical …, 2014 - ACS Publications
Two decades ago, theoretical model calculations played a truly minor role in understanding
mechanisms of redox-active metalloenzymes. The methods available to treat transition …

Real-time time-dependent electronic structure theory

X Li, N Govind, C Isborn, AE DePrince III… - Chemical …, 2020 - ACS Publications
Real-time electronic structure methods provide an unprecedented view of electron dynamics
and ultrafast spectroscopy on the atto-and femtosecond time scale with vast potential to yield …

Homogeneous, Heterogeneous, and Biological Catalysts for Electrochemical N2 Reduction toward NH3 under Ambient Conditions

H Liu, L Wei, F Liu, Z Pei, J Shi, Z Wang, D He… - Acs …, 2019 - ACS Publications
Ammonia (NH3) synthesis is an important industrial chemical process. Recently,
electrochemically converting the earth-abundant dinitrogen (N2) in the aqueous phase to …

Binding of dinitrogen to an iron–sulfur–carbon site

I Čorić, BQ Mercado, E Bill, DJ Vinyard, PL Holland - Nature, 2015 - nature.com
Nitrogenases are the enzymes by which certain microorganisms convert atmospheric
dinitrogen (N2) to ammonia, thereby providing essential nitrogen atoms for higher …

Structural basis of biological nitrogen fixation

DC Rees, F Akif Tezcan, CA Haynes… - … of the Royal …, 2005 - royalsocietypublishing.org
Biological nitrogen fixation is mediated by the nitrogenase enzyme system that catalyses the
ATP dependent reduction of atmospheric dinitrogen to ammonia. Nitrogenase consists of …

Insight into the iron–molybdenum cofactor of nitrogenase from synthetic iron complexes with sulfur, carbon, and hydride ligands

I Čorić, PL Holland - Journal of the American Chemical Society, 2016 - ACS Publications
Nitrogenase enzymes are used by microorganisms for converting atmospheric N2 to
ammonia, which provides an essential source of N atoms for higher organisms. The active …

Critical computational analysis illuminates the reductive-elimination mechanism that activates nitrogenase for N2 reduction

S Raugei, LC Seefeldt… - Proceedings of the …, 2018 - National Acad Sciences
Recent spectroscopic, kinetic, photophysical, and thermodynamic measurements show
activation of nitrogenase for N2→ 2NH3 reduction involves the reductive elimination (re) of …

Studies of low-coordinate iron dinitrogen complexes

JM Smith, AR Sadique, TR Cundari… - Journal of the …, 2006 - ACS Publications
Understanding the interaction of N2 with iron is relevant to the iron catalyst used in the
Haber process and to possible roles of the FeMoco active site of nitrogenase. The work …