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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
Cell type-specific roles of APOE4 in Alzheimer disease
The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …
Astrocytes in selective vulnerability to neurodegenerative disease
Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …
Gliovascular transcriptional perturbations in Alzheimer's disease reveal molecular mechanisms of blood brain barrier dysfunction
To uncover molecular changes underlying blood-brain-barrier dysfunction in Alzheimer's
disease, we performed single nucleus RNA sequencing in 24 Alzheimer's disease and …
disease, we performed single nucleus RNA sequencing in 24 Alzheimer's disease and …
Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery
Over the past decade, single-cell genomics technologies have allowed scalable profiling of
cell-type-specific features, which has substantially increased our ability to study cellular …
cell-type-specific features, which has substantially increased our ability to study cellular …