Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …

Calreticulin (CALR) is an endoplasmic reticulum (ER)-resident protein involved in a
spectrum of cellular processes. In healthy cells, CALR operates as a chaperone and Ca2+ …

Mammalian cells respond to stress by activating mechanisms that support cellular functions
and hence maintain microenvironmental and organismal homeostasis. Intracellular …

Matrix-assisted laser desorption–ionization mass spectrometry imaging in transmission-
mode geometry (t-MALDI–MSI) can provide molecular information with a pixel size of 1 µm …

Reprogramming the immunosuppressive tumor microenvironment by modulating
macrophages holds great promise in tumor immunotherapy. As a class of professional …

Inflammation and its resolution is under-studied in medicine despite being essential for
understanding the development of chronic inflammatory disease. In this review article, we …

Ischemic stroke is the leading cause of human disability and mortality in the world. The main
problem in stroke therapy is the search of efficient neuroprotector capable to rescue neurons …

Apoptosis and the clearance of apoptotic cells are essential processes in animal
development and homeostasis. For apoptotic cells to be cleared, they must display an 'eat …

Tissue-resident macrophages are present in most tissues with developmental, self-renewal,
or functional attributes that do not easily fit into a textbook picture of a plastic and …