Elevated lifetime estrogen exposure is a major risk factor for breast cancer. Recent
advances in the understanding of breast carcinogenesis clearly indicate that induction of …

Malignant tumors display remarkable heterogeneity to the extent that even at the same
tissue site different types of cells with varying genetic background may be found. In contrast …

Background Despite its common use in cancer treatment, radiotherapy has not yet entered
the era of precision medicine, and there have been no approaches to adjust dose based on …

Tumor-associated macrophages (TAMs) have been implicated in the promotion of breast
cancer growth and metastasis, and multiple TAM-secreted cytokines have been identified …

Intratumor heterogeneity is a major clinical problem because tumor cell subtypes display
variable sensitivity to therapeutics and may play different roles in progression. We previously …

Abstract Receptor-interacting protein kinase-3 (RIP3 or RIPK3) is an essential part of the
cellular machinery that executes “programmed” or “regulated” necrosis. Here we show that …

Metabolic reprogramming has been proposed to be a hallmark of cancer, yet a systematic
characterization of the metabolic pathways active in transformed cells is currently lacking …

The epithelial-mesenchymal transition (EMT) is required in the embryo for the formation of
tissues for which cells originate far from their final destination. Carcinoma cells hijack this …

It has long been known that in vitro polarized macrophages differ in morphology. Stemming
from a conventional immunohistology observation, we set out to test the hypothesis that …

Cancer stem cells (CSCs) are proposed to drive tumor initiation and progression. Yet, our
understanding of the cellular and molecular mechanisms that underlie CSC properties is …