The aged adaptive immune system is characterized by progressive dysfunction as well as
increased autoimmunity. This decline is responsible for elevated susceptibility to infection …

MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …

Microglia play a critical role in brain homeostasis and disease progression. In
neurodegenerative conditions, microglia acquire the neurodegenerative phenotype (MGnD) …

MicroRNAs regulate gene expression posttranscriptionally and function within the cells in
which they are transcribed. However, recent evidence suggests that microRNAs can be …

Although T cell help for B cells was described several decades ago, it was the identification
of CXCR5 expression by B follicular helper T (Tfh) cells and the subsequent discovery of …

T follicular helper (TFH) cells are specialized effector CD4+ T cells critical to humoral
immunity. Whether post-transcriptional regulation has a function in TFH cells is unknown …

Bacterial activation of T helper 17 (Th17) cells exacerbates mouse models of autoimmunity,
but how human-associated bacteria impact Th17-driven disease remains elusive. We show …

The aging process is driven by a finite number of inter‐related mechanisms that ultimately
lead to the emergence of characteristic phenotypes, including increased susceptibility to …

The innate inflammatory response must be tightly regulated to ensure effective immune
protection. NF-κB is a key mediator of the inflammatory response, and its dysregulation has …

MicroRNAs (miRNAs or miRs) are a class of evolutionarily-conserved small, regulatory non-
coding RNAs, 19–3 nucleotides in length, that negatively regulate protein coding gene …