This review focuses on the therapeutic effects of ions when released in physiological
environments. Recent studies have shown that metallic ions like Ag+, Sr2+, Mg2+, Mn2+ …

Antibiotic-laden bone substitutes represent a viable option in the treatment of bone and joint
infections with bone defects. In particular, the addition of silver ions or silver nanoparticles to …

Surgical site infection (SSI) is a severe complication associated with orthopedic bone
reconstruction. For both infection prevention and bone regeneration, the framework surface …

Ti surfaces must exhibit antibacterial activity without cytotoxicity to promote bone
reconstruction and prevent infection simultaneously. In this study, we employed a two-step …

In their application in medical devices, zirconium (Zr) and its alloys are expected to prevent
the generation of magnetic resonance imaging artifacts owing to their magnetic …

Scaffolds having appropriate mechanical strength and providing a proper microenvironment
for osteogenesis are expected to be effective alternatives to autografts for bone …

Osteomyelitis is a potentially devastating inflammatory bone disease that leads to bone
destruction and loss. Treatment of osteomyelitis requires the removal of residual bacteria as …

Porous architecture in bone substitutes, notably the interconnectivity of pores, is a critical
factor for bone ingrowth. However, controlling the pore interconnectivity while maintaining …

The repair of DNA damage caused by chemotherapy in cancer cells occurs mainly at two
cell cycle checkpoints (G 1 and G 2) and is a factor contributing to chemoresistance. Most …

Implant-associated infections are threatening and devastating complications that lead to
bone destruction and loss. As a smooth surface is suitable for inhibiting bacterial adhesion …