Advances in MALDI mass spectrometry imaging single cell and tissues

X Zhu, T Xu, C Peng, S Wu - Frontiers in Chemistry, 2022 - frontiersin.org
Compared with conventional optical microscopy techniques, mass spectrometry imaging
(MSI) or imaging mass spectrometry (IMS) is a powerful, label-free analytical technique …

Surface‐assisted laser desorption/ionization mass spectrometry imaging: A review

WH Müller, A Verdin, E De Pauw… - Mass Spectrometry …, 2022 - Wiley Online Library
In the last decades, surface‐assisted laser desorption/ionization mass spectrometry (SALDI‐
MS) has attracted increasing interest due to its unique capabilities, achievable through the …

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) for in situ analysis of endogenous small molecules in biological samples

H Liu, Y Pan, C **ong, J Han, X Wang, J Chen… - TrAC Trends in Analytical …, 2022 - Elsevier
Endogenous small molecules play important roles in biological processes and are closely
related to the occurrence and development of many diseases. Profiling of spatial distribution …

AuNPs/NiFe-LDHs-assisted laser desorption/ionization mass spectrometry for efficient analysis of metronidazole and its metabolites in water samples

L Li, Z Qiu, Y Qi, D Zhao, I Ali, C Sun, L Xu… - Journal of Hazardous …, 2022 - Elsevier
Gold nanoparticles (AuNPs) have been widely used as laser desorption/ionization mass
spectrometry (LDI-MS) nanomaterials for the analysis of low-molecular-weight samples …

Chemical analysis of the human brain by imaging mass spectrometry

A Ajith, Y Sthanikam, S Banerjee - Analyst, 2021 - pubs.rsc.org
Analysis of the chemical makeup of the brain enables a deeper understanding of several
neurological processes. Molecular imaging that deciphers the spatial distribution of …

Mass spectrometry imaging in zebrafish larvae for assessing drug safety and metabolism

M Asslan, N Lauzon, M Beus, D Maysinger… - Analytical and …, 2021 - Springer
Drug safety assessment in the early phases of drug discovery is critical to facilitate the rapid
development of novel therapeutics. Recently, teleost zebrafish (Danio rerio) has emerged as …

Novel technical developments in mass spectrometry imaging in 2020: A mini review

BA Dilmetz, YR Lee, MR Condina… - Analytical Science …, 2021 - Wiley Online Library
The applicability of mass spectrometry imaging (MSI) has exponentially increased with the
improvement of sample preparation, instrumentation (spatial resolution) and data analysis …

FluoMALDI Microscopy: Matrix Co‐Crystallization Simultaneously Enhances Fluorescence and MALDI Imaging

E Yang, XE Shen, H West‐Foyle, TH Hahm… - Advanced …, 2023 - Wiley Online Library
Here, the authors report that co‐crystallization of fluorophores with matrix‐assisted laser
desorption/ionization (MALDI) imaging matrices significantly enhances fluorophore …

Mass Spectrometry Imaging of Organoids to Improve Preclinical Research

C Zivko, TH Hahm, C Tressler, D Brown… - Advanced …, 2024 - Wiley Online Library
Preclinical models are essential research tools before novel therapeutic or diagnostic
methods can be applied to humans. These range from in vitro cell monocultures to vastly …

Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry

GP Lachance, D Gauvreau, É Boisselier… - Sensors, 2024 - mdpi.com
Neurotransmitter analysis plays a pivotal role in diagnosing and managing
neurodegenerative diseases, often characterized by disturbances in neurotransmitter …