Frailty is a multiply determined, age-related state of increased risk for adverse health
outcomes. We review how the degree of frailty conditions the development of late-life …

Cardiac rehabilitation remains the 'Cinderella'of treatments for heart failure. This state-of-the-
art review provides a contemporary update on the evidence base, clinical guidance, and …

2021 Update to the 2017 ACC Expert Consensus Decision Pathway for Optimization of Heart
Failure Treatment: Answers to 10 Pivotal Issues About Heart Failure With Reduced Ejection …

The 2021 Update to the 2017 American College of Cardiology (ACC) Expert Consensus
Decision Pathway for Optimization of Heart Failure Treatment: Answers to 10 Pivotal Issues …

Background: Frailty may modify the risk− benefit profile of certain treatments, and frail
patients may have reduced tolerance to treatments. Objective: To investigate the efficacy of …

At least half of all patients with heart failure (HF) are affected by frailty, a syndrome that limits
an individual ability to recover from acute stressors. While frailty affects up to 90% of patients …

Background: Supervised aerobic exercise training (ET) is recommended for stable
outpatients with heart failure (HF) with reduced ejection fraction (HFrEF). Frailty, a syndrome …

Importance Frailty is common among older patients with acute decompensated heart failure
(ADHF) and is associated with worse quality of life (QOL) and a higher risk of clinical events …

Aims Frailty, characterized by loss of homeostatic reserves and increased vulnerability to
physiological decompensation, results from an aggregation of insults across multiple organ …

Background Frailty is an increasingly common problem, and frail patients are less likely to
receive new pharmacologic therapies because the risk–benefit profile is perceived to be …