Abstract Transposable elements (TEs) comprise~ 50% of our genome, but knowledge of
how TEs affect genome evolution remains incomplete. Leveraging ENCODE4 data, we …

Transposable elements (TEs) are mobile DNA sequences that can insert themselves into
various locations within the genome, causing mutations that may provide advantages or …

Since the turn of the 21st century, genome-wide association study (GWAS) have
successfully identified genetic signals associated with a myriad of common complex traits …

Transposable elements (TEs) provide a source of transcription factor binding sites that can
rewire conserved gene regulatory networks. NF-κB is an evolutionary conserved …

ABSTRACT OF THE DISSERTATION The Evolution of Transposable Elements as Cis-
Regulatory Elements in Mammals for Arts & Sciences Graduate Students by Alan Du Doctor …

The theory of biological evolution has often provoked disagreement, which has frequently
been divisive and counterproductive. At other times this scientific paradigm has been …

Many endogenous retroviruses (ERVs) in the human genome are primate-specific and have
contributed novel cis-regulatory elements and transcripts. However, current approaches for …

Transposable elements (TEs) are mobile genetic elements that make up a large proportion
of mammalian genomes. Although TEs are highly prevalent genomic sequences, they have …

NF-κB is an essential and evolutionarily conserved transcription factor complex primarily
involved in innate immunity and inflammation. In the thesis, I explore how the NF-κB-centric …

The non-coding genome is prevalent in many eukaryotic species and most of it is mapped to
biochemical activity. However, population genetics suggests that a substantial fraction of the …