Drug resistant tuberculosis contributes significantly to the global burden of antimicrobial
resistance, often consuming a large proportion of the healthcare budget and associated …

Antibiotic tolerance is associated with the failure of antibiotic treatment and the relapse of
many bacterial infections. However, unlike resistance, which is commonly measured using …

Persisters are transiently tolerant variants that allow populations to avoid eradication by
antibiotic treatment. Their antibiotic tolerance is non-genetic, not inheritable and results from …

Understanding how antibiotics impact bacterial metabolism may provide insight into their
mechanisms of action and could lead to enhanced therapeutic methodologies. Here, we …

Protein aggregation occurs as a consequence of perturbations in protein homeostasis that
can be triggered by environmental and cellular stresses. The accumulation of protein …

Insufficient development of new antibiotics and the rising resistance of bacteria to those that
we have are putting the world at risk of losing the most widely curative class of medicines …

Infectious diseases caused by clinically important Mycobacteria continue to be an important
public health problem worldwide primarily due to emergence of drug resistance crisis. In …

The remarkable ability of Mycobacterium tuberculosis to survive attacks from the host
immune response and drug treatment is due to the resilience of a few bacilli rather than a …

Polyetheretherketone (PEEK) has been widely used as orthopedic implants, but the poor
antimicrobial and osseointegration properties hinder its advanced clinical applications. Most …

Two parallel revolutions were born in the golden era of antibiotics (~ 1940 to 1960). One
was a revolution in medicine as physicians went to war with microbes. The second was a …