Over the past six decades, the use of ketamine has evolved from an anesthetic and
recreational drug to the first non-monoaminergic antidepressant approved for treatment …

Background Neutrophils are traditionally viewed as first responders but have a short onset of
action in response to traumatic brain injury (TBI). However, the heterogeneity …

Background Brain imaging studies have thoroughly investigated brain gray matter
abnormalities to assess pathophysiological mechanisms underlying psychiatric illnesses …

The human cerebral cortex shows hemispheric asymmetry, yet the microstructural basis of
this asymmetry remains incompletely understood. Here, we probe layer-specific …

Rationale: Adverse experiences in early life including abuse, trauma and neglect, have
been linked to poor physical and mental health outcomes. Emerging evidence implies that …

Whereas meta-analytical data highlight abnormal frontocortical macrostructure
(thickness/surface area/volume) in Major Depressive Disorder (MDD), the underlying …

Background Evidence has established the prominent involvement of rapid eye movement
(REM) sleep disturbance in major depressive disorder (MDD). However, the neural …

Introduction Evidence from previous genetic and post-mortem studies suggested that the
myelination abnormality contributed to the pathogenesis of major depressive disorder …

Abstract 47, XXX (Triple X syndrome) is a sex chromosome aneuploidy characterized by the
presence of a supernumerary X chromosome in affected females and is associated with a …

Background Major depressive disorder (MDD) is associated with disrupted brain structural
integration. Morphometric similarity offers a means to capture the coordinated patterns of …