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Extracellular ATP and P2 purinergic signalling in the tumour microenvironment
F Di Virgilio, AC Sarti, S Falzoni, E De Marchi… - Nature Reviews …, 2018 - nature.com
Modulation of the biochemical composition of the tumour microenvironment is a new frontier
of cancer therapy. Several immunosuppressive mechanisms operate in the milieu of most …
of cancer therapy. Several immunosuppressive mechanisms operate in the milieu of most …
The P2X7 receptor in inflammatory diseases: angel or demon?
LEB Savio, P de Andrade Mello… - Frontiers in …, 2018 - frontiersin.org
Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …
extracellular milieu, being massively released by stressed or dying cells. Once outside the …
Purinergic signalling: therapeutic developments
G Burnstock - Frontiers in pharmacology, 2017 - frontiersin.org
Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …
proposed in 1972. However, this concept was not well accepted until the early 1990's when …
Extracellular purines, purinergic receptors and tumor growth
F Di Virgilio, E Adinolfi - Oncogene, 2017 - nature.com
Virtually, all tumor cells as well as all immune cells express plasma membrane receptors for
extracellular nucleosides (adenosine) and nucleotides (ATP, ADP, UTP, UDP and sugar …
extracellular nucleosides (adenosine) and nucleotides (ATP, ADP, UTP, UDP and sugar …
The P2X7 receptor: A main player in inflammation
E Adinolfi, AL Giuliani, E De Marchi, A Pegoraro… - Biochemical …, 2018 - Elsevier
Damage associated molecular patterns (DAMPs) are intracellular molecules released from
infected or injured cells to activate inflammatory and reparatory responses. One of the most …
infected or injured cells to activate inflammatory and reparatory responses. One of the most …
P2X7 interactions and signaling–making head or tail of it
R Kopp, A Krautloher, A Ramírez-Fernández… - Frontiers in Molecular …, 2019 - frontiersin.org
Extracellular adenine nucleotides play important roles in cell–cell communication and tissue
homeostasis. High concentrations of extracellular ATP released by dying cells are sensed …
homeostasis. High concentrations of extracellular ATP released by dying cells are sensed …
The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression
G Burnstock, GE Knight - Purinergic signalling, 2018 - Springer
Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised.
P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular …
P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular …
P2X7 in cancer: from molecular mechanisms to therapeutics
R Lara, E Adinolfi, CA Harwood, M Philpott… - Frontiers in …, 2020 - frontiersin.org
P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …
The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment
E De Marchi, E Orioli, A Pegoraro, S Sangaletti… - Oncogene, 2019 - nature.com
In the tumor microenvironment (TME) ATP and its receptor P2X7 exert a pivotal influence on
cancer growth and tumor–host interactions. Here we analyzed the different effect of P2X7 …
cancer growth and tumor–host interactions. Here we analyzed the different effect of P2X7 …
Highly‐expressed P2X7 receptor promotes growth and metastasis of human HOS/MNNG osteosarcoma cells via PI3K/Akt/GSK3β/β‐catenin and mTOR/HIF1α/VEGF …
Y Zhang, H Cheng, W Li, H Wu… - International journal of …, 2019 - Wiley Online Library
The P2X7 receptor, an ATP‐gated ion channel, is critical for cancer cell growth,
invasiveness, and angiogenesis. Previous studies indicate that P2X7 regulates osteoblast …
invasiveness, and angiogenesis. Previous studies indicate that P2X7 regulates osteoblast …