Infectious Diseases Society of America 2024 guidance on the treatment of antimicrobial-resistant gram-negative infections

PD Tamma, EL Heil, JA Justo… - Clinical infectious …, 2024 - academic.oup.com
Abstract Background The Infectious Diseases Society of America (IDSA) is committed to
providing up-to-date guidance on the treatment of antimicrobial-resistant (AMR) infections …

Infectious Diseases Society of America guidance on the treatment of AmpC β-lactamase–producing Enterobacterales, carbapenem-resistant Acinetobacter baumannii …

PD Tamma, SL Aitken, RA Bonomo… - Clinical infectious …, 2022 - academic.oup.com
Abstract The Infectious Diseases Society of America (IDSA) is committed to providing up-to-
date guidance on the treatment of antimicrobial-resistant infections. A previous guidance …

Acinetobacter baumannii Antibiotic Resistance Mechanisms

I Kyriakidis, E Vasileiou, ZD Pana, A Tragiannidis - Pathogens, 2021 - mdpi.com
Acinetobacter baumannii is a Gram-negative ESKAPE microorganism that poses a threat to
public health by causing severe and invasive (mostly nosocomial) infections linked with high …

New perspectives on antimicrobial agents: cefiderocol

EK McCreary, EL Heil, PD Tamma - Antimicrobial agents and …, 2021 - Am Soc Microbiol
Bacterial resistance to carbapenem agents has reached alarming levels. Accordingly,
collaborative efforts between national and international organizations and the …

Eradicating biofilm infections: an update on current and prospective approaches

RAG da Silva, I Afonina, KA Kline - Current Opinion in Microbiology, 2021 - Elsevier
Highlights•Biofilm infections are heterogenous, persistent and recalcitrant.•The rise of
antibiotic resistance necessitates new therapeutic strategies to eradicate biofilms.•The …

Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis

Y Imai, G Hauk, J Quigley, L Liang, S Son… - Nature chemical …, 2022 - nature.com
The antimicrobial resistance crisis requires the introduction of novel antibiotics. The use of
conventional broad-spectrum compounds selects for resistance in off-target pathogens and …

Systematic Review of Antimicrobial Combination Options for Pandrug-Resistant Acinetobacter baumannii

S Karakonstantis, P Ioannou, G Samonis, DP Kofteridis - Antibiotics, 2021 - mdpi.com
Antimicrobial combinations are at the moment the only potential treatment option for
pandrug-resistant A. baumannii. A systematic review was conducted in PubMed and Scopus …

Mechanisms and detection methods of Mycobacterium tuberculosis rifampicin resistance: The phenomenon of drug resistance is complex

G Xu, H Liu, X Jia, X Wang, P Xu - Tuberculosis, 2021 - Elsevier
Tuberculosis (TB) is an infectious disease that poses a serious threat to human health.
Rifampin (RIF) is an important first-line anti-TB drug, and rifampin resistance (RIF-R) is a key …

The whole is bigger than the sum of its parts: drug transport in the context of two membranes with active efflux

VV Rybenkov, HI Zgurskaya, C Ganguly… - Chemical …, 2021 - ACS Publications
Cell envelope plays a dual role in the life of bacteria by simultaneously protecting it from a
hostile environment and facilitating access to beneficial molecules. At the heart of this ability …

Pseudomonas aeruginosa FpvB is a high-affinity transporter for xenosiderophores ferrichrome and ferrioxamine B

DCK Chan, LL Burrows - Mbio, 2023 - Am Soc Microbiol
Iron is essential for many biological functions in bacteria, but its poor solubility is a limiting
factor for growth. Bacteria produce siderophores, soluble natural products that bind iron with …