Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …

The adaptive immune system of jawed vertebrates generates a highly diverse repertoire of
antibodies to meet the antigenic challenges of a constantly evolving biological ecosystem …

Structural flexibility in germline gene-encoded antibodies allows promiscuous binding to
diverse antigens. The binding affinity and specificity for a particular epitope typically …

The hepatitis B virus (HBV) core protein is a dynamic and versatile protein that directs many
viral processes. During capsid assembly, core protein allosteric changes ensure efficient …

Objective: To compare performance of contemporary aquaporin-4–immunoglobulin (Ig) G
assays in clinical service. Methods: Sera from neurologic patients (4 groups) and controls …

During the hepatitis B virus (HBV) life cycle, capsid assembly and disassembly must ensure
correct packaging and release of the viral genome. Here we show that changes in the …

Human high-affinity antibodies to pathogens often recognize unrelated ligands. The
molecular origin and the role of this polyreactivity are largely unknown. Here, we report that …

Health is a complex interaction between metabolism, physiology, and immunity. Although it
is difficult to define quantitatively, the activity of the humoral immune system provides a …

The antigen-binding site of Herceptin, an anti-human Epidermal Growth Factor Receptor 2
(HER2) antibody, was engineered to add a second specificity toward Vascular Endothelial …

Antibodies are generated with great diversity in nature resulting in a set of molecules, each
optimized to bind a specific target. Taking advantage of their diversity and specificity …