ADAR1: from basic mechanisms to inhibitors
J Rehwinkel, P Mehdipour - Trends in Cell Biology, 2024 - cell.com
Adenosine deaminase acting on RNA 1 (ADAR1) converts adenosine to inosine in double-
stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 deficiency in …
stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 deficiency in …
Limited dsRNA editing impedes leukemia stem cells
Understanding the mechanisms underlying the generation and maintenance of leukemia
stem cells (LSCs) is crucial for the development of effective therapies against T cell acute …
stem cells (LSCs) is crucial for the development of effective therapies against T cell acute …
Nuclear eNOS interacts with and S-nitrosates ADAR1 to modulate type I interferon signaling and endothelial function
X Zhou, C Kuenne, S Günther, I Wittig, B Güven… - bioRxiv, 2024 - biorxiv.org
Background Nitric oxide (NO) generated by the endothelial NO synthase (eNOS) regulates
vascular tone and endothelial homeostasis to counteract vascular inflammation. Most eNOS …
vascular tone and endothelial homeostasis to counteract vascular inflammation. Most eNOS …
Identification and characterization of ADAR1 mutations and changes in gene expression in human cancers
A Valentine, K Bosart, W Bush, RA Bouley… - Cancer Genetics, 2024 - Elsevier
ADAR1 (Adenosine deaminase action on RNA1) is involved in post-transcriptional RNA
editing. ADAR1 mutations have been identified in many cancers but its role in tumor …
editing. ADAR1 mutations have been identified in many cancers but its role in tumor …
Advances of RNA editing in hematopoiesis and associated malignancies
Abstract Adenosine-to-inosine (A-to-I) RNA editing is a prevalent RNA modification essential
for cell survival. The process is catalyzed by the Adenosine Deaminase Acting on RNA …
for cell survival. The process is catalyzed by the Adenosine Deaminase Acting on RNA …
[HTML][HTML] Protocol for in vitro co-culture assay for rapid expansion of human T cell acute lymphoblastic leukemia
T cell acute lymphoblastic leukemia (T-ALL) is a rare but aggressive hematological cancer
that occurs primarily in children and adolescents. Here, we present a protocol for in vitro co …
that occurs primarily in children and adolescents. Here, we present a protocol for in vitro co …