The clinical responses observed following treatment with immune checkpoint inhibitors
(ICIs) support immunotherapy as a potential anticancer treatment. However, a large …

Several studies in recent years have demonstrated that gut microbiota–host interactions play
an important role in human health and disease, including inflammatory and cardiovascular …

Ulcerative colitis (UC) and Crohn's disease (CD), collectively known as Inflammatory Bowel
Diseases (IBD), are caused by a complex interplay between genetic, immunologic, microbial …

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …

Cardiovascular diseases (CVD) are major causes of death worldwide. Recently, new roles
for intestinal microbiota in pathology and treatment of CVD have been proposed. Butyrate, a …