The emergence of lncRNAs in cancer biology

JR Prensner, AM Chinnaiyan - Cancer discovery, 2011 - AACR
The discovery of numerous noncoding RNA (ncRNA) transcripts in species from yeast to
mammals has dramatically altered our understanding of cell biology, especially the biology …

Emerging roles of long non‐coding RNA in cancer

A Sanchez Calle, Y Kawamura, Y Yamamoto… - Cancer …, 2018 - Wiley Online Library
Since comprehensive analysis of the mammalian genome revealed that the majority of
genomic products are transcribed in long non‐coding RNA (lnc RNA), increasing attention …

microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer

C Braconi, T Kogure, N Valeri, N Huang, G Nuovo… - Oncogene, 2011 - nature.com
The human genome is replete with long non-coding RNAs (lncRNA), many of which are
transcribed and likely to have a functional role. Microarray analysis of> 23 000 lncRNAs …

MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches

N Amodio, L Raimondi, G Juli, MA Stamato… - Journal of hematology & …, 2018 - Springer
The deeper understanding of non-coding RNAs has recently changed the dogma of
molecular biology assuming protein-coding genes as unique functional biological effectors …

[HTML][HTML] The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine

P Qi, X Du - Modern pathology, 2013 - Elsevier
The conventional view of gene regulation in biology has centered around protein-coding
genes via the central dogma of DNA→ mRNA→ protein. The discovery of thousands of long …

Large non-coding RNAs: missing links in cancer?

M Huarte, JL Rinn - Human molecular genetics, 2010 - academic.oup.com
Cellular homeostasis is achieved by the proper balance of regulatory networks that if
disrupted can lead to cellular transformation. These cell circuits are fine-tuned and …

Long non-coding RNA: a new player in cancer

H Zhang, Z Chen, X Wang, Z Huang, Z He… - Journal of hematology & …, 2013 - Springer
Emerging evidence showed that long non-coding RNAs (lncRNAs) play important roles in a
wide range of biological processes and dysregulated lncRNAs are involved in many …

[HTML][HTML] Regulation of lncRNA and its role in cancer metastasis

J Li, H Meng, Y Bai, K Wang - Oncology research, 2016 - ncbi.nlm.nih.gov
Metastasis is the primary cause of cancer-related death all over the world. Metastasis is a
process by which cancer spreads from the place at which it first arose to distant locations in …

Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets

V Kameswaran, NC Bramswig, LB McKenna, M Penn… - Cell metabolism, 2014 - cell.com
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the
insulin-producing β cells in the endocrine pancreas to overcome insulin resistance in …

Non-coding RNAs as mediators of epigenetic changes in malignancies

S Kumar, EA Gonzalez, P Rameshwar, JP Etchegaray - Cancers, 2020 - mdpi.com
Simple Summary This review discusses the role of non-coding RNAs (ncRNAs) in cancer
epigenetics, mostly focusing on how deregulated microRNAs (miRNAs) and long non …