Brain GABA levels across psychiatric disorders: A systematic literature review and meta‐analysis of 1H‐MRS studies

RR Schür, LWR Draisma, JP Wijnen… - Human brain …, 2016 - Wiley Online Library
The inhibitory gamma‐aminobutyric acid (GABA) system is involved in the etiology of most
psychiatric disorders, including schizophrenia, autism spectrum disorder (ASD) and major …

Psychological and biological mechanisms linking trauma with cardiovascular disease risk

JA Sumner, S Cleveland, T Chen, JL Gradus - Translational psychiatry, 2023 - nature.com
Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, and
experiences of psychological trauma have been associated with subsequent CVD onset …

Oxidative stress, inflammation, and neuroprogression in chronic PTSD

MW Miller, AP Lin, EJ Wolf… - Harvard review of …, 2018 - journals.lww.com
Posttraumatic stress disorder is a serious and often disabling syndrome that develops in
response to a traumatic event. Many individuals who initially develop the disorder go on to …

Prefrontal excitatory/inhibitory balance in stress and emotional disorders: evidence for over-inhibition

CE Page, L Coutellier - Neuroscience & Biobehavioral Reviews, 2019 - Elsevier
Chronic stress-induced emotional disorders like anxiety and depression involve imbalances
between the excitatory glutamatergic system and the inhibitory GABAergic system in the …

Is post-traumatic stress disorder associated with premature senescence? A review of the literature

JB Lohr, BW Palmer, CA Eidt, S Aailaboyina… - The American Journal of …, 2015 - Elsevier
Objective Post-traumatic stress disorder (PTSD) has major public health significance.
Evidence that PTSD may be associated with premature senescence (early or accelerated …

Single-prolonged stress: a review of two decades of progress in a rodent model of post-traumatic stress disorder

MJ Lisieski, AL Eagle, AC Conti, I Liberzon… - Frontiers in …, 2018 - frontiersin.org
Post-traumatic stress disorder (PTSD) is a common, costly, and often debilitating psychiatric
condition. However, the biological mechanisms underlying this disease are still largely …

Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies

LA Averill, P Purohit, CL Averill, MA Boesl, JH Krystal… - Neuroscience …, 2017 - Elsevier
Posttraumatic stress disorder (PTSD) is a chronic and debilitating psychiatric disorder
afflicting millions of individuals across the world. While the availability of robust …

Glutathione in the human brain: Review of its roles and measurement by magnetic resonance spectroscopy

CD Rae, SR Williams - Analytical biochemistry, 2017 - Elsevier
We review the transport, synthesis and catabolism of glutathione in the brain as well as its
compartmentation and biochemistry in different brain cells. The major reactions involving …

Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: relevance for sex differences in stress-related disorders

R Shepard, CE Page, L Coutellier - Neuroscience, 2016 - Elsevier
Stress-induced modifications of the prefrontal cortex (PFC) are believed to contribute to the
onset of mood disorders, such as depression and anxiety, which are more prevalent in …

Threshold Modulative Artificial GABAergic Nociceptor

G Kim, Y Lee, JB Jeon, WH Cheong, W Park… - Advanced …, 2023 - Wiley Online Library
Gamma‐aminobutyric acid (GABA) is a crucial inhibitory neurotransmitter of the central
nervous system. It modifies the signal threshold of the nociceptor, allowing it to react to …