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Neuroinflammation, stroke, blood-brain barrier dysfunction, and imaging modalities
Maintaining blood-brain barrier (BBB) integrity is crucial for the homeostasis of the central
nervous system. Structurally comprising the BBB, brain endothelial cells interact with …
nervous system. Structurally comprising the BBB, brain endothelial cells interact with …
Inflammatory responses after ischemic stroke
Ischemic stroke generates an immune response that contributes to neuronal loss as well as
tissue repair. This is a complex process involving a range of cell types and effector …
tissue repair. This is a complex process involving a range of cell types and effector …
Immune responses to stroke: mechanisms, modulation, and therapeutic potential
Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …
Immune cells in the BBB disruption after acute ischemic stroke: targets for immune therapy?
Y Qiu, C Zhang, A Chen, H Wang, Y Zhou… - Frontiers in …, 2021 - frontiersin.org
Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …
Gut microbiota–derived short-chain fatty acids promote poststroke recovery in aged mice
J Lee, J d'Aigle, L Atadja, V Quaicoe… - Circulation …, 2020 - ahajournals.org
Rationale: The elderly experience profound systemic responses after stroke, which
contribute to higher mortality and more severe long-term disability. Recent studies have …
contribute to higher mortality and more severe long-term disability. Recent studies have …
Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment
The prevalence of cerebrovascular disease increases with age, placing the elderly at a
greater lifetime risk for dementia. Vascular cognitive impairment (VCI) encompasses a …
greater lifetime risk for dementia. Vascular cognitive impairment (VCI) encompasses a …
Glial cells: role of the immune response in ischemic stroke
Ischemic stroke, which accounts for 75–80% of all strokes, is the predominant cause of
morbidity and mortality worldwide. The post-stroke immune response has recently emerged …
morbidity and mortality worldwide. The post-stroke immune response has recently emerged …
The IL-17 family of cytokines in health and disease
The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A
through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 th …
through IL-17F. IL-17A, the prototypical member of this family, just passed the 25 th …
The influence of gut dysbiosis in the pathogenesis and management of ischemic stroke
Recent research on the gut microbiome has revealed the influence of gut microbiota (GM)
on ischemic stroke pathogenesis and treatment outcomes. Alterations in the diversity …
on ischemic stroke pathogenesis and treatment outcomes. Alterations in the diversity …
Interleukin‐18: Biological properties and role in disease pathogenesis
G Kaplanski - Immunological reviews, 2018 - Wiley Online Library
Initially described as an interferon (IFN) γ‐inducing factor, interleukin (IL)‐18 is indeed
involved in Th1 and NK cell activation, but also in Th2, IL‐17‐producing γδ T cells and …
involved in Th1 and NK cell activation, but also in Th2, IL‐17‐producing γδ T cells and …