Shining new light on biological systems: luminescent transition metal complexes for bioimaging and biosensing applications

LCC Lee, KKW Lo - Chemical Reviews, 2024 - ACS Publications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species

KG Fosnacht, MD Pluth - Chemical Reviews, 2024 - ACS Publications
Hydrogen sulfide (H2S) is not only a well-established toxic gas but also an important small
molecule bioregulator in all kingdoms of life. In contemporary biology, H2S is often classified …

Strategic Design of Luminescent Rhenium (I), Ruthenium (II), and Iridium (III) Complexes as Activity‐Based Probes for Bioimaging and Biosensing

LCC Lee, KKW Lo - Chemistry–An Asian Journal, 2022 - Wiley Online Library
The rapid development of responsive fluorescent probes has advanced optical imaging for
biological research and biomedical applications. Among different sensing strategies, activity …

Photoinduction of Ferroptosis and cGAS-STING Activation by a H2S-Responsive Iridium(III) Complex for Cancer-Specific Therapy

Y Li, B Liu, Y Zheng, M Hu, LY Liu, CR Li… - Journal of Medicinal …, 2024 - ACS Publications
Triggering ferroptosis represents a promising anticancer therapeutic strategy, but the
development of a selective ferroptosis inducer for cancer-specific therapy remains a great …

Design and synthesis of two iridium (Ⅲ) complex probes for rapid sensing of hydrogen sulfide

X Mu, W Zhang, MJ Li, F Fu - Sensors and Actuators B: Chemical, 2024 - Elsevier
Hydrogen sulfide (H 2 S) is an important sulfur-containing signaling molecule in the human
body, as well as a highly toxic gas that is soluble in water. A variety of pathological …

Mitochondria-targeted cyclometalated iridium (III) complex for H2S-responsive intracellular redox regulation as potent photo-oxidation anticancer agent

B Liu, X Huang, M Hu, Z Chen, W Zhang… - JBIC Journal of Biological …, 2022 - Springer
Owing to the safety and low toxicity, photodynamic therapy (PDT) for cancer treatment has
received extensive attention. However, the excess H2S in cancer cells reduces the PDT …

Recent advances in luminescent lanthanides and transition metal complex-based probes for imaging reactive oxygen, nitrogen, and sulfur species in living cells

R Sivakumar, NY Lee - Coordination Chemistry Reviews, 2024 - Elsevier
Reactive oxygen, nitrogen, and sulfur species (RONSS) regulate several pathological
activities in biological systems. These RONSS can be seriously harmful to the human body …

Fluorescent probes for detecting and imaging mitochondrial hydrogen sulfide

YW Zhu, EE Ngowi, AQ Tang, T Chu, Y Wang… - Chemico-Biological …, 2025 - Elsevier
Hydrogen sulfide (H 2 S) is a potent redox-active signaling molecule commonly
dysregulated in disease states. The production of H 2 S and its involvement in various …

Inducing and monitoring mitochondrial pH changes with an iridium (iii) complex via two-photon lifetime imaging

M Hu, XL Zhou, TX **ao, L Hao, Y Li - Dalton Transactions, 2023 - pubs.rsc.org
Real-time monitoring of mitochondrial dynamic changes plays a key role in the development
of mitochondria-targeted anticancer theranostic agents. In this work, a pH-responsive and …

Four cyclometalated Ir (iii) complexes and insights into their luminescence, cytotoxicity and DNA/BSA binding performance

Q Yu, S Gu, X Yang, Q Jiang, P Shi - RSC advances, 2024 - pubs.rsc.org
Four cyclometalated Ir (III) complexes based on 4′-pN, N-bis (2-hydroxyethyl) benzyl-2,
2′: 6′, 2′′-terpyridine (TPYOH) and 4′-pN, N-bis (2-hydroxyethyl) benzyl-6′-benzyl …