Scientific rationale for develo** potent RBD-based vaccines targeting COVID-19
H Kleanthous, JM Silverman, KW Makar, IK Yoon… - npj Vaccines, 2021 - nature.com
Vaccination of the global population against COVID-19 is a great scientific, logistical, and
moral challenge. Despite the rapid development and authorization of several full-length …
moral challenge. Despite the rapid development and authorization of several full-length …
[HTML][HTML] Mutations of SARS-CoV-2 spike protein: Implications on immune evasion and vaccine-induced immunity
Responsible for more than 4.9 million deaths so far, COVID-19, caused by SARS-CoV-2, is
instigating devastating effects on the global health care system whose impacts could be …
instigating devastating effects on the global health care system whose impacts could be …
SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies
Several variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have
emerged during the current coronavirus disease 2019 (COVID-19) pandemic. Although …
emerged during the current coronavirus disease 2019 (COVID-19) pandemic. Although …
SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines
JE Bowen, YJ Park, C Stewart, JT Brown… - Science …, 2022 - science.org
Numerous safe and effective coronavirus disease 2019 vaccines have been developed
worldwide that use various delivery technologies and engineering strategies. We show here …
worldwide that use various delivery technologies and engineering strategies. We show here …
SARS-CoV-2 ferritin nanoparticle vaccines elicit broad SARS coronavirus immunogenicity
MG Joyce, WH Chen, RS Sankhala, A Hajduczki… - Cell reports, 2021 - cell.com
The need for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) next-
generation vaccines has been highlighted by the rise of variants of concern (VoCs) and the …
generation vaccines has been highlighted by the rise of variants of concern (VoCs) and the …
Current and future nanoparticle vaccines for COVID-19
COVID-19 has become a major cause of global mortality and driven massive health and
economic disruptions. Mass global vaccination offers the most efficient pathway towards …
economic disruptions. Mass global vaccination offers the most efficient pathway towards …
Instructing durable humoral immunity for COVID-19 and other vaccinable diseases
D Bhattacharya - Immunity, 2022 - cell.com
Many aspects of SARS-CoV-2 have fully conformed with the principles established by
decades of viral immunology research, ultimately leading to the crowning achievement of …
decades of viral immunology research, ultimately leading to the crowning achievement of …
Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity
WH Chen, A Hajduczki, EJ Martinez, H Bai… - Nature …, 2023 - nature.com
Despite rapid and ongoing vaccine and therapeutic development, SARS-CoV-2 continues to
evolve and evade, presenting a need for next-generation diverse therapeutic modalities …
evolve and evade, presenting a need for next-generation diverse therapeutic modalities …
Deciphering triterpenoid saponin biosynthesis by leveraging transcriptome response to methyl jasmonate elicitation in Saponaria vaccaria
Methyl jasmonate (MeJA) is a known elicitor of plant specialized metabolism, including
triterpenoid saponins. Saponaria vaccaria is an annual herb used in traditional Chinese …
triterpenoid saponins. Saponaria vaccaria is an annual herb used in traditional Chinese …
A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge
KMG Wuertz, EK Barkei, WH Chen, EJ Martinez… - npj Vaccines, 2021 - nature.com
The emergence of SARS-CoV-2 variants of concern (VOC) requires adequate coverage of
vaccine protection. We evaluated whether a SARS-CoV-2 spike ferritin nanoparticle vaccine …
vaccine protection. We evaluated whether a SARS-CoV-2 spike ferritin nanoparticle vaccine …