Overview of microRNA biogenesis, mechanisms of actions, and circulation

J O'Brien, H Hayder, Y Zayed, C Peng - Frontiers in endocrinology, 2018 - frontiersin.org
MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating
gene expression. The majority of miRNAs are transcribed from DNA sequences into primary …

Action mechanisms and research methods of tRNA-derived small RNAs

Y ** by RNA in gene regulatory elements
AA Sigova, BJ Abraham, X Ji, B Molinie, NM Hannett… - Science, 2015 - science.org
Transcription factors (TFs) bind specific sequences in promoter-proximal and-distal DNA
elements to regulate gene transcription. RNA is transcribed from both of these DNA …

RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond

SE Castel, RA Martienssen - Nature Reviews Genetics, 2013 - nature.com
A growing number of functions are emerging for RNA interference (RNAi) in the nucleus, in
addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm …

[HTML][HTML] MicroRNA directly enhances mitochondrial translation during muscle differentiation

X Zhang, X Zuo, B Yang, Z Li, Y Xue, Y Zhou, J Huang… - Cell, 2014 - cell.com
MicroRNAs are well known to mediate translational repression and mRNA degradation in
the cytoplasm. Various microRNAs have also been detected in membrane …

Chromatin-associated RNAs as facilitators of functional genomic interactions

X Li, XD Fu - Nature Reviews Genetics, 2019 - nature.com
Mammalian genomes are extensively transcribed, which produces a large number of both
coding and non-coding transcripts. Various RNAs are physically associated with chromatin …

Metazoan promoters: emerging characteristics and insights into transcriptional regulation

B Lenhard, A Sandelin, P Carninci - Nature Reviews Genetics, 2012 - nature.com
Promoters are crucial for gene regulation. They vary greatly in terms of associated regulatory
elements, sequence motifs, the choice of transcription start sites and other features. Several …