Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

During starvation, fasting, or a diet containing little digestible carbohydrates, the circulating
insulin levels are decreased. This promotes lipolysis, and the breakdown of fat becomes the …

Exercise has long been known for its active role in improving physical fitness and sustaining
health. Regular moderate-intensity exercise improves all aspects of human health and is …

Accumulating evidence supports that physical exercise (EX) is the most effective non-
pharmacological strategy to improve brain health. EX prevents cognitive decline associated …

Background and aims: Currently there is considerable interest in ketone metabolism owing
to recently reported benefits of ketosis for human health. Traditionally, ketosis has been …

Background Exercise changes the concentrations of many metabolites, which are small
molecules (< 1.5 kDa) metabolized by the reactions of human metabolism. In recent years …

While the timing of food intake is important, it is unclear whether the effects of exercise on
energy metabolism are restricted to unique time windows. As circadian regulation is key to …

The ability of ketogenic low‐carbohydrate (CHO) high‐fat (K‐LCHF) diets to enhance
muscle fat oxidation has led to claims that it is the 'future of elite endurance sport'. There is …

The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) have pleiotropic
effects in multiple organs including brain, heart, and skeletal muscle by serving as an …

As a metabolic organ, adipose tissue plays an important role in regulating metabolism. In
adults, most adipose tissue is white adipose tissue (WAT), and excessive expansion of WAT …