Alveolar macrophages (AMs) are the sentinel cells of the alveolar space, maintaining
homeostasis, fending off pathogens, and controlling lung inflammation. During acute lung …

T cells are an important component of adaptive immunity and protect the host from infectious
diseases and cancers. However, uncontrolled T cell immunity may cause autoimmune …

Abstract Arachidonic acid (AA), a 20 carbon chain polyunsaturated fatty acid with 4 double
bonds, is an integral constituent of biological cell membrane, conferring it with fluidity and …

Pathogen infection causes a stereotyped state of sickness that involves neuronally
orchestrated behavioural and physiological changes,. On infection, immune cells release a …

Controlled immune responses to infection and injury involve complex molecular signalling
networks with coordinated and often opposing actions. Eicosanoids and related bioactive …

Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …

Active inflammation generally promotes immune activation. However, in the tumor
microenvironment (TME), active inflammation occurs in parallel with immunosuppression …

The mechanisms by which melanoma and other cancer cells evade anti-tumor immunity
remain incompletely understood. Here, we show that the growth of tumors formed by mutant …

Studies have shown that infection, excessive coagulation, cytokine storm, leukopenia,
lymphopenia, hypoxemia and oxidative stress have also been observed in critically ill …

Summary COVID-19, caused by SARS-CoV-2, is characterised by a broad spectrum of
symptom severity that requires varying amounts of care according to the different stages of …