Neuroinflammatory mechanisms in ischemic stroke: focus on cardioembolic stroke, background, and therapeutic approaches

CD Maida, RL Norrito, M Daidone… - International journal of …, 2020 - mdpi.com
One of the most important causes of neurological morbidity and mortality in the world is
ischemic stroke. It can be a result of multiple events such as embolism with a cardiac origin …

Inflammatory processes in cardiovascular disease: a route to targeted therapies

N Ruparelia, JT Chai, EA Fisher… - Nature reviews …, 2017 - nature.com
Inflammatory processes are firmly established as central to the development and
complications of cardiovascular diseases. Elevated levels of inflammatory markers have …

CD28− T cells: their role in the age-associated decline of immune function

N Weng, AN Akbar, J Goronzy - Trends in immunology, 2009 - cell.com
The accumulation of CD28− T cells, particularly within the CD8 subset, is one of the most
prominent changes during T-cell homeostasis and function associated with aging in …

Accelerated atherosclerosis in autoimmune rheumatic diseases

Y Shoenfeld, R Gerli, A Doria, E Matsuura, MM Cerinic… - Circulation, 2005 - Am Heart Assoc
antibodies concomitant with larger atherosclerotic lesions that contained abundant CD4
cells. OxLDL is the type of LDL that is more likely to undergo uptake by macrophages, which …

Heat-shock proteins induce T-cell regulation of chronic inflammation

W Van Eden, R Van der Zee, B Prakken - Nature Reviews Immunology, 2005 - nature.com
Immune responses to certain heat-shock proteins (HSPs) develop in almost all inflammatory
diseases; however, the significance of such responses is only now becoming clear. In …

Pathogenesis of acute coronary syndromes

F Crea, G Liuzzo - Journal of the American College of Cardiology, 2013 - jacc.org
Experimental models of atherogenesis have provided a growing body of information about
molecular mechanisms of plaque growth; however, transition from coronary stability to …

Role of lymphocytes in myocardial injury, healing, and remodeling after myocardial infarction

U Hofmann, S Frantz - Circulation research, 2015 - Am Heart Assoc
A large body of evidence produced during decades of research indicates that myocardial
injury activates innate immunity. On the one hand, innate immunity both aggravates …

Innate immune signaling in cardiac ischemia

F Arslan, DP De Kleijn, G Pasterkamp - Nature Reviews Cardiology, 2011 - nature.com
Despite advances in treatment of patients who suffer from ischemic heart disease, morbidity
related to myocardial infarction is increasing in Western societies. Acute and chronic …

Mechanisms of disease: atherosclerosis in autoimmune diseases

Y Sherer, Y Shoenfeld - Nature clinical practice Rheumatology, 2006 - nature.com
Atherosclerosis is a pathologic process affecting blood vessels, which leads to the
development of cardiovascular disease. The immune system is involved in atherogenesis …

The influence of innate and adaptive immune responses on atherosclerosis

JL Witztum, AH Lichtman - Annual Review of Pathology …, 2014 - annualreviews.org
Both the chronic development of atherosclerotic lesions and the acute changes in lesion
phenotype that lead to clinical cardiovascular events are significantly influenced by the …