[HTML][HTML] Inhaled amikacin to prevent ventilator-associated pneumonia
S Ehrmann, F Barbier, J Demiselle… - … England Journal of …, 2023 - Mass Medical Soc
Background Whether preventive inhaled antibiotics may reduce the incidence of ventilator-
associated pneumonia is unclear. Methods In this investigator-initiated, multicenter, double …
associated pneumonia is unclear. Methods In this investigator-initiated, multicenter, double …
ICU-acquired infections in immunocompromised patients
Immunocompromised patients account for an increasing proportion of the typical intensive
care unit (ICU) case-mix. Because of the increased availability of new drugs for cancer and …
care unit (ICU) case-mix. Because of the increased availability of new drugs for cancer and …
Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections
Critically ill patients in intensive care units experience profound alterations of their gut
microbiota that have been linked to a high risk of hospital-acquired (nosocomial) infections …
microbiota that have been linked to a high risk of hospital-acquired (nosocomial) infections …
Association between selective decontamination of the digestive tract and in-hospital mortality in intensive care unit patients receiving mechanical ventilation: a …
Importance The effectiveness of selective decontamination of the digestive tract (SDD) in
critically ill adults receiving mechanical ventilation is uncertain. Objective To determine …
critically ill adults receiving mechanical ventilation is uncertain. Objective To determine …
Trends in ICU mortality and underlying risk over three decades among mechanically ventilated patients. A group level analysis of cohorts from infection prevention …
JC Hurley - Annals of Intensive Care, 2023 - Springer
Background Has either the underlying risk or the mortality incidence among ICU patients
receiving mechanical ventilation (MV) in the literature changed in recent decades …
receiving mechanical ventilation (MV) in the literature changed in recent decades …
Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19
M Trøseid, JC Holter, K Holm, B Vestad, T Sazonova… - Critical Care, 2023 - Springer
Background Gut microbiota alterations have been reported in hospitalized COVID-19
patients, with reduced alpha diversity and altered microbiota composition related to …
patients, with reduced alpha diversity and altered microbiota composition related to …
Surviving sepsis after burn campaign
Abstract Introduction The Surviving Sepsis Campaign was developed to improve outcomes
for all patients with sepsis. Despite sepsis being the primary cause of death after thermal …
for all patients with sepsis. Despite sepsis being the primary cause of death after thermal …
Positive single-center randomized trials and subsequent multicenter randomized trials in critically ill patients: a systematic review
Background It is unclear how often survival benefits observed in single-center randomized
controlled trials (sRCTs) involving critically ill patients are confirmed by subsequent …
controlled trials (sRCTs) involving critically ill patients are confirmed by subsequent …
Empirical antibiotic therapy for sepsis: save the anaerobic microbiota
Antibiotics are fundamental in sepsis management; however, the optimal empirical treatment
remains debated. Despite anaerobes rarely being the causative pathogen of sepsis …
remains debated. Despite anaerobes rarely being the causative pathogen of sepsis …
Gut microbiome-based therapeutics in critically ill adult patients—a narrative review
S He, F Lin, X Hu, P Pan - Nutrients, 2023 - mdpi.com
The gut microbiota plays a crucial role in the human microenvironment. Dysbiosis of the gut
microbiota is a common pathophysiological phenomenon in critically ill patients. Therefore …
microbiota is a common pathophysiological phenomenon in critically ill patients. Therefore …