Epigenetic mechanisms, which include DNA methylation, histone modification, and
microRNA (miRNA), can produce heritable phenotypic changes without a change in DNA …

Cancer initiation and proliferation is regulated by both epigenetic and genetic events with
epigenetic modifications being increasingly identified as important targets for cancer …

Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

Although the inflammation‐associated cytokine interleukin‐6 (IL‐6) has been implicated in
cholangiocarcinoma growth, the relationship between IL‐6 and oncogenic changes is …

DNA methylation is an epigenetic process involved in development, aging, and cancer.
Although the advent of new molecular techniques has enhanced our knowledge of how …

The rising incidence of breast cancer has been a significant source of concern in the
medical community. Regarding the adverse effects and consequences of current treatments …

Background The inflammatory cytokine interleukin-6 (IL-6) is critical for the expression of
octamer-binding transcription factor 4 (OCT4), which is highly associated with early tumor …

Hepatocellular carcinoma (HCC) is one of most lethal cancers worldwide. Strategic
decisions for the advancement of molecular therapies in this neoplasm require a clear …

Epigenetic alterations and microRNA (miRNA) deregulation are common in hepatocellular
carcinoma (HCC). The histone H3 lysine 27 (H3K27) tri‐methylating enzyme, enhancer of …