Parkinson's disease (PD) is a devastating and highly prevalent neurodegenerative disease
for which only symptomatic treatment is available. In order to develop a truly effective …

A number of different intracellular signaling pathways have been shown to be activated by
receptor tyrosine kinases. These activation events include the phosphoinositide 3-kinase, 70 …

Apoptosis plays an important role during neuronal development, and defects in apoptosis
may underlie various neurodegenerative disorders. To characterize molecular mechanisms …

The dual threats of the depletion of nonrenewable energy and environmental pollution
caused by petroleum-based polymers motivate utilization of naturally occurring polymers to …

Embryogenesis is in some way a model system. It has always been distinguished bythe
aeactitude, evn punctio, of its anatomical descriptions. An experiment by one of the great …

ABSTRACT A battery of monoclonal antibodies (mAbs) against brain cell nuclei has been
generated by repeated immunizations. One of these, mAb A60, recognizes a vertebrate …

The classical studies of nicotine by Langley at the turn of the 20th century introduced the
concept of a “receptive substance,” from which the idea of a “receptor” came to light …

Summary Amyloid 3 protein (Af3) is a 40-43 amino acid peptide that Is associated with
plaques in the brains of Alzheimer's patients and is cytotoxic to cultured neurons. Using both …

Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a
profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions …

Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the
substantia nigra and the formation of aggregates (Lewy bodies) in neurons. α-Synuclein is …