Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's
expressed genes and then transport and display this antigenic information on the cell …

The endoplasmic reticulum (ER) uses an elaborate surveillance system called the ER
quality control (ERQC) system. The ERQC facilitates folding and modification of secretory …

Background Approximately 50 to 60% of patients with essential thrombocythemia or primary
myelofibrosis carry a mutation in the Janus kinase 2 gene (JAK2), and an additional 5 to …

Neuroinflammation and endoplasmic reticulum (ER) stress are associated with many
neurological diseases. Here, we have examined the interaction between ER stress and …

The endoplasmic reticulum (ER) is a multifunctional intracellular organelle supporting many
processes required by virtually every mammalian cell, including cardiomyocytes. It performs …

Protein disulfide isomerases (PDIs) are enzymes that mediate oxidative protein folding in the
endoplasmic reticulum. Understanding of PDIs has historically been hampered by lack of …

Helenius and colleagues proposed over 20‐years ago a paradigm‐shifting model for how
chaperone binding in the endoplasmic reticulum was mediated and controlled for a new …

The site of protein folding and maturation for the majority of proteins that are secreted,
localized to the plasma membrane or targeted to endomembrane compartments is the …

Endoplasmic reticulum (ER) is an essential sub‐cellular compartment of the eukaryotic cell
performing many diverse functions essential for the cell and the whole organism. ER …

The expression patterns of clock‐controlled genes (ccgs) are regulated by circadian rhythm,
which is a major regulatory and physiological mechanism tied to the solar day. Disruptions …