Background Cancer cells possess a common metabolic phenotype, rewiring their metabolic
pathways from mitochondrial oxidative phosphorylation to aerobic glycolysis and anabolic …

Background and Purpose—Multipotent mesenchymal stromal cell (MSC) harvested
exosomes are hypothesized as the major paracrine effectors of MSCs. In vitro, the miR-17 …

Neural diseases such as compressive, congenital, and traumatic injuries have diverse
consequences, from benign mild sequelae to severe life-threatening conditions with …

The transcription factor Pax5 controls B cell development, but its role in mature B cells is
largely enigmatic. Here, we demonstrated that the loss of Pax5 by conditional mutagenesis …

Converging clinical and preclinical evidence demonstrates that depressive phenotypes are
associated with synaptic dysfunction and dendritic simplification in cortico-limbic …

Traumatic spinal cord injury (TSCI) leads to pathological changes such as inflammation,
edema, and neuronal apoptosis. Methylprednisolone (MP) is a glucocorticoid that has a …

Schwann cells switch to a repair phenotype following peripheral nerve injury and create a
favorable microenvironment to drive nerve repair. Many microRNAs (miRNAs) are …

New players are emerging in the game of peripheral and central nervous system injury since
their physiopathological mechanisms remain partially elusive. These mechanisms are …

Neural stem cells (NSCs) can generate new neurons to repair brain injury and central
nervous system disease by promoting neural regeneration. MicroRNAs (miRNAs) involve in …

Emerging evidence indicates that microRNAs play an important role in neural remodeling,
including neurite growth, after acute spinal cord injury (ASCI). This study aims to identify the …