Helicobacter pylori is a class one carcinogen which causes chronic atrophic gastritis, gastric
intestinal metaplasia, dysplasia and adenocarcinoma. The mechanisms by which H. pylori …

Introduction Germline mutation in CDH1 (E-cadherin) tumor suppressor gene is associated
with hereditary diffuse gastric cancer (HDGC) and lobular breast cancers (LBC). E-Cadherin …

Background: The protumor activities of cancer-associated fibroblasts (CAFs) suggest that
they are potential therapeutic targets for the treatment of cancer. The mechanism of CAF …

Simple Summary Germline BRCA1 and BRCA2 pathogenic variant carriers are recognized
to be at increased risk for multiple cancers including breast, ovarian, pancreatic, and …

Gastric cancer is the third most common cause of cancer-related death worldwide. Diffuse-
type gastric cancer (DGC) is a particularly aggressive subtype that is both difficult to detect …

Approximately 5.0% of gastric cancer (GC) patients are diagnosed before the age of 40 and
are not candidates for screening programs in most countries and regions. The incidence of …

Extracellular vesicles (EVs) are cell-derived vesicles important in intercellular
communication that play an essential role in host-pathogen interactions, spreading …

The prevalence of gastric cancer has markedly declined, but due to the high mortality rates
associated with gastric cancer, it is still a serious disease. The preferred classification of …

Diffuse-type gastric cancer (DGC) is a subtype of gastric cancer that is prone to peritoneal
dissemination, with poor patient prognosis. Although intercellular adhesion loss between …

Background Diffuse-type gastric cancer (DGC), for which Helicobacter pylori infection is a
causal factor, is associated with poor prognosis among young women, possibly due to …