The role of small airways in obstructive airway diseases

PR Burgel - European respiratory review, 2011 - Eur Respiratory Soc
This review article is a summary of a seminar organised by the European Respiratory
Society on “The role of small airways in obstructive airway diseases” which was held in …

Imaging of lung function using hyperpolarized helium‐3 magnetic resonance imaging: review of current and emerging translational methods and applications

S Fain, ML Schiebler, DG McCormack… - Journal of magnetic …, 2010 - Wiley Online Library
During the past several years there has been extensive development and application of
hyperpolarized helium‐3 (HP 3He) magnetic resonance imaging (MRI) in clinical respiratory …

Expanding applications of pulmonary MRI in the clinical evaluation of lung disorders: Fleischner Society position paper

H Hatabu, Y Ohno, WB Gefter, G Parraga, B Madore… - Radiology, 2020 - pubs.rsna.org
Pulmonary MRI provides structural and quantitative functional images of the lungs without
ionizing radiation, but it has had limited clinical use due to low signal intensity from the lung …

Protocols for multi‐site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar‐airspace size, and gas exchange: A position paper from the 129Xe …

PJ Niedbalski, CS Hall, M Castro… - Magnetic resonance …, 2021 - Wiley Online Library
Hyperpolarized (HP) 129Xe MRI uniquely images pulmonary ventilation, gas exchange, and
terminal airway morphology rapidly and safely, providing novel information not possible …

Chronic Obstructive Pulmonary Disease: Safety and Tolerability of Hyperpolarized 129Xe MR Imaging in Healthy Volunteers and Patients

B Driehuys, S Martinez-Jimenez, ZI Cleveland… - Radiology, 2012 - pubs.rsna.org
Purpose To evaluate the safety and tolerability of inhaling multiple 1-L volumes of undiluted
hyperpolarized xenon 129 (129Xe) followed by up to a 16-second breath hold and magnetic …

Hyperpolarized gas MR imaging: technique and applications

JE Roos, HP McAdams, SS Kaushik… - Magnetic Resonance …, 2015 - mri.theclinics.com
Lung diseases affect the conducting airways, the gas exchange parenchyma, or both. As a
result, they have a high impact on patients' morbidity, and quality of life. Chronic obstructive …

Functional imaging of the lungs with gas agents

SJ Kruger, SK Nagle, MJ Couch, Y Ohno… - Journal of Magnetic …, 2016 - Wiley Online Library
This review focuses on the state‐of‐the‐art of the three major classes of gas contrast agents
used in magnetic resonance imaging (MRI)—hyperpolarized (HP) gas, molecular oxygen …

Catch-up Alveolarization in Ex-Preterm Children. Evidence from 3He Magnetic Resonance

M Narayanan, CS Beardsmore… - American journal of …, 2013 - atsjournals.org
Rationale: Histologic data from fatal cases suggest that extreme prematurity results in
persisting alveolar damage. However, there is new evidence that human alveolarization …

Lung MRI with hyperpolarised gases: current & future clinical perspectives

NJ Stewart, LJ Smith, HF Chan… - The British Journal of …, 2022 - academic.oup.com
The use of pulmonary MRI in a clinical setting has historically been limited. Whilst CT
remains the gold-standard for structural lung imaging in many clinical indications, technical …

Lung damage and airway remodelling in severe asthma

CE Brightling, S Gupta, S Gonem… - Clinical & Experimental …, 2012 - Wiley Online Library
Severe asthma is a heterogeneous disease with substantial unmet clinical need. Airway
damage and remodelling is a consequence of complex host–environment interactions and …