Evolution and implications of de novo genes in humans
Genes and translated open reading frames (ORFs) that emerged de novo from previously
non-coding sequences provide species with opportunities for adaptation. When aberrantly …
non-coding sequences provide species with opportunities for adaptation. When aberrantly …
De Novo Genes
Although the majority of annotated new genes in a given genome appear to have arisen
from duplication-related mechanisms, recent studies have shown that genes can also …
from duplication-related mechanisms, recent studies have shown that genes can also …
Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames
All species continuously evolve short open reading frames (sORFs) that can be templated
for protein synthesis and may provide raw materials for evolutionary adaptation. We …
for protein synthesis and may provide raw materials for evolutionary adaptation. We …
What can ribo-seq, immunopeptidomics, and proteomics tell us about the noncanonical proteome?
Abstract Ribosome profiling (Ribo-Seq) has proven transformative for our understanding of
the human genome and proteome by illuminating thousands of noncanonical sites of …
the human genome and proteome by illuminating thousands of noncanonical sites of …
Selection of a de novo gene that can promote survival of Escherichiacoli by modulating protein homeostasis pathways
Cellular novelty can emerge when non-functional loci become functional genes in a process
termed de novo gene birth. But how proteins with random amino acid sequences …
termed de novo gene birth. But how proteins with random amino acid sequences …
Evolutionary trajectories of new duplicated and putative de novo genes
JC Montañés, M Huertas, X Messeguer… - Molecular biology and …, 2023 - academic.oup.com
The formation of new genes during evolution is an important motor of functional innovation,
but the rate at which new genes originate and the likelihood that they persist over longer …
but the rate at which new genes originate and the likelihood that they persist over longer …
Large-scale investigation of species-specific orphan genes in the human gut microbiome elucidates their evolutionary origins
Species-specific genes, also known as orphans, are ubiquitous across life's domains. In
prokaryotes, species-specific orphan genes (SSOGs) are mostly thought to originate in …
prokaryotes, species-specific orphan genes (SSOGs) are mostly thought to originate in …
Shining a light on the dark proteome: Non‐canonical open reading frames and their encoded miniproteins as a new frontier in cancer biology
In the decades following the discovery that genes encode proteins, scientists have tried to
exhaustively and comprehensively characterize the human genome. Recent advances in …
exhaustively and comprehensively characterize the human genome. Recent advances in …
Microproteins—Discovery, structure, and function
Advances in proteogenomic technologies have revealed hundreds to thousands of
translated small open reading frames (sORFs) that encode microproteins in genomes across …
translated small open reading frames (sORFs) that encode microproteins in genomes across …
[HTML][HTML] Evolution of translational control and the emergence of genes and open reading frames in human and non-human primate hearts
Evolutionary innovations can be driven by changes in the rates of RNA translation and the
emergence of new genes and small open reading frames (sORFs). In this study, we …
emergence of new genes and small open reading frames (sORFs). In this study, we …