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Polymeric delivery of therapeutic nucleic acids
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
Driving polymer brushes from synthesis to functioning
The great success of controlled radical polymerizations has encouraged researchers to
develop more facile and robust approaches for surface‐initiated polymerizations (SIPs) to …
develop more facile and robust approaches for surface‐initiated polymerizations (SIPs) to …
Responsive polymer brush design and emerging applications for nanotheranostics
Responsive polymer brushes are a category of polymer brushes that are capable of
conformational and chemical changes in response to external stimuli. They offer unique …
conformational and chemical changes in response to external stimuli. They offer unique …
Recent advances in formulation and application of molecular polymer brushes in biomedicine: Therapeutic, diagnostic, and theranostics capabilities
The applications of nanotechnology in medical sciences, especially in drug and gene
delivery, has experienced unprecedented growth in recent years. The integration of …
delivery, has experienced unprecedented growth in recent years. The integration of …
Polycation architecture and assembly direct successful gene delivery: micelleplexes outperform polyplexes via optimal DNA packaging
Z Tan, Y Jiang, W Zhang, L Karls… - Journal of the …, 2019 - ACS Publications
Cellular delivery of biomacromolecules is vital to medical research and therapeutic
development. Cationic polymers are promising and affordable candidate vehicles for these …
development. Cationic polymers are promising and affordable candidate vehicles for these …
A guide to functionalisation and bioconjugation strategies to surface-initiated polymer brushes
Since the first introduction of their concept in the 1980s and 90s, polymer brushes have
been the focus of intense research efforts to identify novel physico-chemical properties and …
been the focus of intense research efforts to identify novel physico-chemical properties and …
Interactions between polymeric nanoparticles and different buffers as investigated by zeta potential measurements and molecular dynamics simulations
Zeta potential is an essential surface parameter in the characterization of nanoparticles,
determined at the interface of loosely bound ions (diffuse layer) at the nanoparticle surface …
determined at the interface of loosely bound ions (diffuse layer) at the nanoparticle surface …
Tailoring the architecture of cationic polymer brush-modified carbon nanotubes for efficient sirna delivery in cancer immunotherapy
The facile and controlled fabrication of homogeneously grafted cationic polymers on carbon
nanotubes (CNTs) remains poorly investigated, which further hinders the understanding of …
nanotubes (CNTs) remains poorly investigated, which further hinders the understanding of …
Immune checkpoint reprogramming via sequential nucleic acid delivery strategy optimizes systemic immune responses for gastrointestinal cancer immunotherapy
Z Li, X Liu, N Cai, Z Zhou, H Huang, Q Wu, L Xu… - Cancer Letters, 2024 - Elsevier
Monoclonal antibodies targeting immune checkpoints have been widely applied in
gastrointestinal cancer immunotherapy. However, systemic administration of various …
gastrointestinal cancer immunotherapy. However, systemic administration of various …
Packaging pDNA by polymeric ABC micelles simultaneously achieves colloidal stability and structural control
Compaction of DNA by oppositely charged nanoparticles is a fundamental phenomenon in
nature and of great interest to develo** therapeutics. In addition, the ability to orthogonally …
nature and of great interest to develo** therapeutics. In addition, the ability to orthogonally …