Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

Dihydrofuranocoumarin, chalepin (1) and furanocoumarin, chalepensin (2) are 3-prenylated
bioactive coumarins, first isolated from the well-known medicinal plant Ruta chalepensis …

Coumarins, also known as benzopyrones, are present in remarkable amounts in plants,
although their presence has also been detected in microorganisms and animal sources. The …

A total of 39 endophytic fungi have been isolated from Viguiera arenaria and Tithonia
diversifolia, both collected in São Paulo State, Brazil. The isolates were identified based on …

The structure of the glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH)
from Trypanosoma cruzi complexed with chalepin, a natural product from Pilocarpus …

Amoebiasis caused by Entamoeba histolytica is associated with high morbidity and mortality
is becoming a major public health problem worldwide, especially in develo** countries …

Chagas' disease, a parasitic infection caused by the flagellate protozoan Trypanosoma
cruzi, is a major public health problem affecting millions of individuals in Latin America. On …

Natural and synthetic coumarins have been described as prototypes of new drug candidates
against Chagas' disease. During a typical screening with new compounds, we observed the …

The in vitro trypanocidal activity of 22 extracts and 43 fractions of plants belonging to the
families Meliaceae and Rutaceae was evaluated. The extracts from leaves of …

Chagas' disease, caused by Trypanosoma cruzi, is endemic in 15 countries in Latin
America. In this work a library of 38 coumarins was prepared in solution phase and …