Microbial production of advanced biofuels

J Keasling, H Garcia Martin, TS Lee… - Nature Reviews …, 2021 - nature.com
Concerns over climate change have necessitated a rethinking of our transportation
infrastructure. One possible alternative to carbon-polluting fossil fuels is biofuels produced …

Using genome-scale models to predict biological capabilities

EJ O'Brien, JM Monk, BO Palsson - Cell, 2015 - cell.com
Constraint-based reconstruction and analysis (COBRA) methods at the genome scale have
been under development since the first whole-genome sequences appeared in the mid …

Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v. 3.0

L Heirendt, S Arreckx, T Pfau, SN Mendoza… - Nature protocols, 2019 - nature.com
Constraint-based reconstruction and analysis (COBRA) provides a molecular mechanistic
framework for integrative analysis of experimental molecular systems biology data and …

Metabolic burden: cornerstones in synthetic biology and metabolic engineering applications

G Wu, Q Yan, JA Jones, YJ Tang, SS Fong… - Trends in …, 2016 - cell.com
Engineering cell metabolism for bioproduction not only consumes building blocks and
energy molecules (eg, ATP) but also triggers energetic inefficiency inside the cell. The …

Systems metabolic engineering of microorganisms for natural and non-natural chemicals

JW Lee, D Na, JM Park, J Lee, S Choi… - Nature chemical biology, 2012 - nature.com
Growing concerns over limited fossil resources and associated environmental problems are
motivating the development of sustainable processes for the production of chemicals, fuels …

[HTML][HTML] Dynamic control in metabolic engineering: Theories, tools, and applications

CJ Hartline, AC Schmitz, Y Han, F Zhang - Metabolic engineering, 2021 - Elsevier
Metabolic engineering has allowed the production of a diverse number of valuable
chemicals using microbial organisms. Many biological challenges for improving bio …

New applications of synthetic biology tools for cyanobacterial metabolic engineering

M Santos-Merino, AK Singh, DC Ducat - Frontiers in bioengineering …, 2019 - frontiersin.org
Cyanobacteria are promising microorganisms for sustainable biotechnologies, yet unlocking
their potential requires radical re-engineering and application of cutting-edge synthetic …

OptCom: a multi-level optimization framework for the metabolic modeling and analysis of microbial communities

AR Zomorrodi, CD Maranas - PLoS computational biology, 2012 - journals.plos.org
Microorganisms rarely live isolated in their natural environments but rather function in
consolidated and socializing communities. Despite the growing availability of high …

Phytostilbenes as agrochemicals: Biosynthesis, bioactivity, metabolic engineering and biotechnology

P Jeandet, A Vannozzi, E Sobarzo-Sánchez… - Natural product …, 2021 - pubs.rsc.org
Covering: 1976 to 2020. Although constituting a limited chemical family, phytostilbenes
represent an emblematic group of molecules among natural compounds. Ever since their …

A genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains

A Khodayari, CD Maranas - Nature communications, 2016 - nature.com
Kinetic models of metabolism at a genome scale that faithfully recapitulate the effect of
multiple genetic interventions would be transformative in our ability to reliably design novel …