Skeletal muscle fat infiltration (known as myosteatosis) is an ectopic fat depot that increases
with aging and is recognized to negatively correlate with muscle mass, strength, and mobility …

Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and
degraded bone microstructure, which leads to increased bone fragility and risks of bone …

Skeletal muscle and bone share common embryological origins from mesodermal cell
populations and also display common growth trajectories early in life. Moreover, muscle and …

Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

Understanding the interaction mechanisms between nanomaterials and biological cells is
important for the control and manipulation of these interactions for biomedical applications …

Aging and a sedentary lifestyle conspire to reduce bone quantity and quality, decrease
muscle mass and strength, and undermine postural stability, culminating in an elevated risk …

Mechanobiology has underpinned many scientific advances in understanding how
biophysical and biomechanical cues regulate cell behavior by identifying mechanosensitive …

Background As common progenitor cells of osteoblasts and adipocytes, bone marrow
mesenchymal (stromal) stem cells (BMSCs) play key roles in bone homeostasis, tissue …

Obesity is associated with increased risk for fragility fractures. However, the cellular
mechanisms are unknown. Using a translational approach combining RNA sequencing and …

Bone marrow-derived mesenchymal stem and stromal cells (MSCs) are promising
candidates for cell-based therapies in diverse conditions including tissue engineering …