Targeting Akt/CREB/BDNF signaling pathway by ginsenosides in neurodegenerative diseases: A mechanistic approach

SN Zarneshan, S Fakhri, H Khan - Pharmacological research, 2022 - Elsevier
Neurodegenerative diseases (NDDs) are leading causes of death and morbidity in the
elderly worldwide. From the mechanistic/pathological view, oxidative stress, inflammation …

[HTML][HTML] Neuroprotective natural products' regulatory effects on depression via gut–brain axis targeting tryptophan

H Liaqat, A Parveen, SY Kim - Nutrients, 2022 - mdpi.com
L-tryptophan (Trp) contributes to regulating bilateral communication of the gut–brain axis. It
undergoes three major metabolic pathways, which lead to formation of kynurenine …

Direct and indirect evidences of BDNF and NGF as key modulators in depression: role of antidepressants treatment

AC Mondal, M Fatima - International Journal of Neuroscience, 2019 - Taylor & Francis
Purpose: Depression is one of the most prevalent, recurrent and life-threatening mental
illnesses. However, the precise mechanism underlying the disorder is not yet clearly …

Electro-acupuncture alleviates chronic unpredictable stress-induced depressive-and anxiety-like behavior and hippocampal neuroinflammation in rat model of …

N Yue, B Li, L Yang, QQ Han, HJ Huang… - Frontiers in Molecular …, 2018 - frontiersin.org
Depression is the second leading cause of disability worldwide. The effects of clinical
depression may be mediated by neuroinflammation such as activation of microglia and high …

Effects of chronic unpredictable mild stress induced prenatal stress on neurodevelopment of neonates: role of GSK-3β

M Fatima, S Srivastav, MH Ahmad, AC Mondal - Scientific reports, 2019 - nature.com
Prenatal stress (PNS) has gained attention with regard to its impact on hippocampal
neurogenesis in neonates which serves as a risk factor for postnatal neurodevelopmental …

Botanicals as modulators of neuroplasticity: focus on BDNF

E Sangiovanni, P Brivio, M Dell'Agli… - Neural …, 2017 - Wiley Online Library
The involvement of brain‐derived neurotrophic factor (BDNF) in different central nervous
system (CNS) diseases suggests that this neurotrophin may represent an interesting and …

[HTML][HTML] SiNiSan ameliorates depression-like behavior in rats by enhancing synaptic plasticity via the CaSR-PKC-ERK signaling pathway

C Shen, K Cao, S Cui, Y Cui, H Mo, W Wen… - Biomedicine & …, 2020 - Elsevier
Background Adverse stress in early life negatively influences psychiatric health by
increasing the risk of develo** depression and suicide in adulthood. Clinical …